Protective Effect of  on the Movement Renal Ischemia-reperfusion in Rats

GUO Ai-min; CAO Jian-min; ZHOU Hai-tao; ZHENG Meng-jun; LI Lin-na

doi:10.11653/syfj2013180232

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Protective Effect of on the Movement Renal Ischemia-reperfusion in Rats

更新时间：2024-01-04

- Protective Effect of on the Movement Renal Ischemia-reperfusion in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 18, Pages: 232-236(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013180232
  CLC：
- Published：2013
- 稿件说明：
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GUO Ai-min, CAO Jian-min, ZHOU Hai-tao, et al. Protective Effect of on the Movement Renal Ischemia-reperfusion in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(18): 232-236.
DOI：

GUO Ai-min, CAO Jian-min, ZHOU Hai-tao, et al. Protective Effect of on the Movement Renal Ischemia-reperfusion in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(18): 232-236. DOI： 10.11653/syfj2013180232.

摘要

目的: 研究菟丝子对大鼠运动性肾缺血再灌注损伤的保护作用及机制。方法: 将7周龄雄性Wistar大鼠75只为对象随机分为4组:对照组(C组

12只)、一般训练组(M组

12只)、过度训练组(OM组

24只)、菟丝子+过度训练组(COM组

24只)

进行56 d的力竭游泳训练。菟丝子+过度训练组灌胃(ig)给药

每天1次

剂量为6.96 g·kg-1

ig体积为5 mL·kg-1;其他各组ig等量生理盐水。末次训练后24 h

进行血清尿素氮、血清肌酐等生化指标检测。结果: 8周的过度训练导致大鼠运动性肾缺血"再灌注"

自由基代谢紊乱

肾组织超微结构被严重破坏、组织病理学发生明显改变

肾功能受到严重损坏。血尿素氮和血清肌酐:过度训练组、菟丝子+过度训练组高于对照组(P<0.01);菟丝子+过度训练组低于过度训练组(P<0.05)。SOD活性:过度训练组、菟丝子+过度训练组低于对照组(P<0.01);菟丝子+过度训练组高于过度训练组(P<0.05)。MDA含量:过度训练组、菟丝子+过度训练组高于对照组(P<0.01)

菟丝子+过度训练组低于过度训练组(P<0.05)。结论: 菟丝子改善了过度训练大鼠肾缺血再灌注所引起的自由基代谢紊乱

肾脏超微结构趋于正常

对运动性缺血再灌注肾脏具有保护作用。

Abstract

Objective: To study Cuscuta chinensis. protective effect and mechanism of movement renal ischemia-reperfusion injury in rats. Method: Divided the 75 7-week-old male Wistar rats into 4 groups randomly:control group (group C

12)

general training group (group M

12)

overtraining group (group OM

24)

C. chinensis+overtraining group (group COM

24)

56 days of exhaustive swimming training. The COM group with professional gavages for gastric lavage (ig) once a day

the dose was 6.96 g·kg-1 and ig volume was 5 mL·kg-1;other groups were for ig normal saline. Detect biochemical parameters of serum urea nitrogen and serum creatinine after 24 hours when the last training ends. Result: In the 8 week of overtraining rats resulted in movement of ‘renal ischemia reperfusion’ and disordered free radicals metabolism. The ultrastructure of kidney was severely damaged

the histopathological changes obviously

and renal function was seriously damaged. Serum creatinine and blood urea nitrogen of OM group and COM group were higher than in group C (P<0.01); COM group was lower than the OM group (P<0.05). SOD activity of OM group and COM group were lower than in group C (P<0.01); COM group was higher than the OM group (P<0.05). The content of MDA in OM group and COM group was higher than in group C (P<0.01); COM group was lower than the OM group (P<0.05). Conclusion: C. chinensis can improve disordered free radicals metabolism in overtraining rats which is caused by renal ischemia reperfusion. Kidney ultramicrostructure is normal. Moreover

it has a protective effect on exercise-induced ischemia-reperfusion kidney.

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