Experimental Study of Zishui Qinggan Yin Treat Adverse Effect Caused by Breast Cancer Endocrine Therapy

SUN Shao-mei; CAO Peng; HUO Jie-ge; HU Chun-ping; WANG Xiao-ning; HU Can-hong; NIE Dong-hui

doi:10.11653/syfj2013180256

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Experimental Study of Zishui Qinggan Yin Treat Adverse Effect Caused by Breast Cancer Endocrine Therapy

更新时间：2024-01-04

- Experimental Study of Zishui Qinggan Yin Treat Adverse Effect Caused by Breast Cancer Endocrine Therapy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 18, Pages: 256-259(2013)
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- DOI：10.11653/syfj2013180256
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- Published：2013
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SUN Shao-mei, CAO Peng, HUO Jie-ge, et al. Experimental Study of Zishui Qinggan Yin Treat Adverse Effect Caused by Breast Cancer Endocrine Therapy[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(18): 256-259.
DOI：

SUN Shao-mei, CAO Peng, HUO Jie-ge, et al. Experimental Study of Zishui Qinggan Yin Treat Adverse Effect Caused by Breast Cancer Endocrine Therapy[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(18): 256-259. DOI： 10.11653/syfj2013180256.

摘要

目的: 探讨滋水清肝饮对内分泌治疗后的去卵巢大鼠血清雌激素、血脂及子宫内膜厚度的影响。方法: 去卵巢大鼠用来曲唑(0.23 mg·kg-1)建立乳腺癌患者内分泌治疗的类更年期症状模型;大鼠随机分为5组:假手术组、模型对照组、阳性药组(莉芙敏0.026 g·kg-1)、滋水清肝饮(11.28

45.10 g·kg-1)组

去卵巢术后2周开始ig给药

1次/d

连续6周。每7天测量大鼠体重。给药6周后腹主动脉取血

检测雌二醇(E2)、孕酮(内膜厚度PRO)、总胆固醇(CHO)、甘油三酯(TG)

高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平

镜下观察子宫内膜厚度。结果: 滋水清肝饮高、低剂量组体重均低于模型组(P<0.05);滋水清肝饮高剂量组E2

PRO较模型组降低(P<0.05);.滋水清肝饮高剂量组CHO

TG显著降低(P<0.05)

高剂量组明显升高LDL-C;滋水清肝饮和莉芙敏组的子宫内膜厚度与模型组无明显差别。结论: 滋水清肝饮可以改善内分泌治疗的去卵巢大鼠的血脂

并不会引起雌激素水平的升高和子宫内膜增厚。

Abstract

Objective: To investigate the effect of Zishui Qinggan Yin (ZSQGY) on estrogen level

cholesterol level and the endometrial thickness of ovariectomized rats after endocrine therapy. Method: Ovariectomized rats were treated with Letrozole(0.23 mg·kg-1)to mimic climacteric syndrome of breast cancer patient after endocrine therapy. Rats were randomly divided into five groups(n=7) and were orally administered corresponding drugs once per day for 6 weeks:sham group

model control group

positive control group(Remifemin 0.026 g·kg-1)

ZSQGY high and low dose group(45.10

11.28 g·kg-1). The body weight of rats was recorded each week. After the treatment

blood plasma was collected by abdominal aortic method

plasma estradiol(E2)

progesterone(PRO)

total cholesterol(CHO)

triglycerides(TG)

high density lipoprotein cholesterd(HDL-C)

low density lipoprotein cholesterd(LDL-C) were detected

pathological detection was processed by endometrium thickness. Result: After treatment

the average weight of ZSQGY high and low group were lower than that of model group(P<0.05). Compared with model group

the serum level of E2

PRO

CHO

LDL-C of ESQGY were significantly decreased (P<0.05) which were still higher than sham group; the serum level of HDL-C of ESQGY high dose group was incseased(P<0.05).The ZSQGY groups and remifemin group have no obvious difference in endometrium thickness compared with the model group. Conclusion: ZSQGY can reduce the blood lipid without increasing the E2

PRO level and endometrium thickness.

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