Objective: To study the anti-inflammatory effect and acute toxicity of total polyphenols from Elaeagnus angustifolia seeds. Method: Sixty Kunming mice were randomly divided into five groups:modle group

aspirin group (200 mg·kg-1) and total polyphenols from Eiangustifolia(90

180

360 mg·kg-1)groups

once a day for 7 continuous days

xylene induced mouse ear edema was used to assess the anti-inflammatory ability. One hurdred and eighty Sprague Dawley rats were randomly divided into modle group

aspirin group (165 mg·kg-1) and the total polyphenols from Eiangustifolia(75

150

300 mg·kg-1) groups. After treatment

the anti-inflammatory effects of total polyphenols from Eiangustifolia were observed with rats pow swollen induced by carrageenan

rats skin capillary permeability induced by acetic acid and rats granuloma caused by embedded tampon. Maximal tolerance dose (MTD) with oral administration was used for acute toxicity test. Result: Compared with the modle group

total polyphenols from Eiangustifolia have a significantly effect to decrease ear edema induced by Xylene (P<0.05) and pow swollen induced by carrageenan (P<0.01). Compared with the modle group

granuloma of tampon and kin capillary permeability were decreased significantly (P<0.01) respectively. MTD of total polyphenols from Eiangustifolia was 160 g·kg-1. Conclusion: Total polyphenols from E. angustifolia seeds performed anti-inflammatory activity with low toxity.