Development of Release Methods in Lipid Nanoparticles Drug Delivery System

WANG Lan; LIU Ying; FENG Nian-ping

doi:10.11653/syfj2013180350

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Development of Release Methods in Lipid Nanoparticles Drug Delivery System

更新时间：2024-01-04

- Development of Release Methods in Lipid Nanoparticles Drug Delivery System
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 18, Pages: 350-356(2013)
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- DOI：10.11653/syfj2013180350
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- Published：2013
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WANG Lan, LIU Ying, FENG Nian-ping. Development of Release Methods in Lipid Nanoparticles Drug Delivery System[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(18): 350-356.
DOI：

WANG Lan, LIU Ying, FENG Nian-ping. Development of Release Methods in Lipid Nanoparticles Drug Delivery System[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(18): 350-356. DOI： 10.11653/syfj2013180350.

摘要

通过查阅近几年国内外相关文献

进行归纳整理并分类

介绍了近年来有关经典体外释放方法、透析法、室扩散法、流池法、基于体外脂解模型的体外释放研究方法等体外测定方法在药物释放特性评价中的应用进展。脂质纳米粒给药系统是近年来发展较快的一类药物传递系统

评价脂质纳米粒的指标主要有粒径、Zeta电位、载药量、体外释放、稳定性等。药物释放是影响药物进入体内发挥药效的重要因素之一

故体外释放是评价脂质纳米粒质量的重要指标

也是控制制剂质量的重要手段。但是如何建立一种更加科学合理的体外释放方法使其具有较好的预测性则需要科学工作者进一步研究优化

促进脂质纳米粒给药系统的研究与开发。

Abstract

In this paper

we summarized the development of in-vitro release methods

including typical in vitro release method

dialysis bags or tube diffusion method

Franz diffusion cell method

Flow through cell method

in-vitro release method based on in vitro lipolysis model. Lipid nanoparticles are one of rapid developed drug delivery systems in recent years. The indicators to evaluate the lipid nanoparticles are mainly particle size

Zeta potential

drug loadings

in vitro release

stability and so on. Drug release from the carriers is one of the key factors affecting drug performance in vivo

so the in vitro release is the important one to control the quality of the lipid nanoparticles.

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