Study on Chemical Constituents of Fructus

CHEN Lin; MU Shu-zhen; YAN Chen; HUANG Lie-jun; HAO Xiao-jiang

doi:10.11653/syfj201318090

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Study on Chemical Constituents of Fructus

更新时间：2024-01-04

- Study on Chemical Constituents of Fructus
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 18, Pages: 90-95(2013)
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- DOI：10.11653/syfj201318090
  CLC：
- Published：2013
- 稿件说明：
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CHEN Lin, MU Shu-zhen, YAN Chen, et al. Study on Chemical Constituents of Fructus [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(18): 90-95.
DOI：

CHEN Lin, MU Shu-zhen, YAN Chen, et al. Study on Chemical Constituents of Fructus [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(18): 90-95. DOI： 10.11653/syfj201318090.

摘要

目的: 研究黔产川楝子中的化学成分。方法: 应用正、反相硅胶(RP-18型)柱层析;葡聚糖凝胶(Sephadex LH-20型)柱层析

结合重结晶方法进行分离纯化

运用1H-NMR

13C-NMR

ESI-MS和ES-MS等现代波谱技术对化合物的结构进行鉴定。结果: 从黔产川楝子乙醇提取物中分离鉴定了12个化合物

分别被鉴定为:1-O-tigloyl-1-O-debenzoylohchinal (1)

印楝醛 (ohchinal

1-cinnamoyltrichilinin (3)

7-diacetyl-14

15-deoxyhavanensin (4)

7-O-acetyl-14

15-deoxyhavanensin (5)

6α-O-acetyl-7-deacetylnimocinol (6)

6α-hydroxyazadirone (7)

24-Nor-5ξ-13α

17α-chola-14

22-triene-3β

7α-diol-21

23-epoxy-4

8-trimethyl-3-acetate (8)

hedyotol-A (9)

6-bis(3-methoxy-4-hydroxyphenyl)-3

7-dioxabicyclo[3

0]octan-8-one (10)

exo-endo-2

6-bis(4'-hydroxy-3'-methoxy-phenyl)-3

7-dioxabicyclo[3

0] octane (11)和betulafolienediolone (12)。结论: 化合物 2~12均为首次从该植物中分离得到。

Abstract

Objective: To study the chemical constituents of fructus Melia toosendan. Method: Normal phase silica gel

RP-18 Silica gel and Sephadex LH-20 column chromatographies combined with recrystallization were used to isolate and purify the constituents. Their structures were identifided by spectroscopic methods

including 1H-NMR

13C-NMR

ESI-MS and EI-MS. Result: Twelve compounds were isolated. Their structures were decided as 1-O-tigloyl-1-O-debenzoylohchinal (1)

ohchinal (2)

1-cinnamoyltrichilinin (3)

7-diacetyl-14

15-deoxyhavanensin (4)

7-O-acetyl-14

15-deoxyhavanensin (5)

6α-O-acetyl-7-deacetylnimocinol (6)

6α-hydroxyazadirone (7)

24-nor-5ξ-13α

17α-chola-14

22-triene-3β

7α-diol-21

23-epoxy-4

8-trimethyl-3-acetate (8)

hedyotol-A (9)

6-bis(3-methoxy-4-hydroxyphenyl)-3

7-dioxabicyclo[3

0]octan-8-one (10)

exo-endo-2

6-bis(4'-hydroxy-3'-methoxy-phenyl)-3

7-dioxabicyclo[3

0]octane (11) and betulafolienediolone (12). Conclusion: Compounds 2-12 were obtained from fructus M. toosendan for the first time.

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