Optimization of Atmospheric Pressure Boiling Technology of Buyang Huanwu Decoction

ZHANG Yuan; ZHOU Qin-mei; LIU Shun; ZHU Qi-hui; CAI Bao-chang

doi:10.11653/syfj2013190005

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Optimization of Atmospheric Pressure Boiling Technology of Buyang Huanwu Decoction

更新时间：2024-01-04

- Optimization of Atmospheric Pressure Boiling Technology of Buyang Huanwu Decoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 19, Pages: 5-8(2013)
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- DOI：10.11653/syfj2013190005
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- Published：2013
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ZHANG Yuan, ZHOU Qin-mei, LIU Shun, et al. Optimization of Atmospheric Pressure Boiling Technology of Buyang Huanwu Decoction[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(19): 5-8.
DOI：

ZHANG Yuan, ZHOU Qin-mei, LIU Shun, et al. Optimization of Atmospheric Pressure Boiling Technology of Buyang Huanwu Decoction[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(19): 5-8. DOI： 10.11653/syfj2013190005.

摘要

目的: 考察两煎常压煎药机不同煎煮条件对补阳还五汤剂质量的影响。方法: 采用单因素试验考察加水量水平

以总固体、阿魏酸及黄芪甲苷含量为综合评价指标

通过正交试验考察加水量、浸泡时间、煎煮次数及煎煮时间对煎煮工艺的影响

利用HPLC测定阿魏酸及黄芪甲苷含量。结果: 方差分析表明各因素对煎煮工艺的影响顺序为煎煮次数>加水量>煎煮时间>浸泡时间

其中煎煮次数具有显著性影响

其余3个因素均无显著性影响。最佳常压煎煮工艺为加8~10倍量水浸泡30 min

煎煮2次

每次60 min。结论: 优选的工艺稳定可行

为两煎常压煎药机制备含黄芪甲苷及阿魏酸的中药汤剂提供理论依据。

Abstract

Objective: To investigate effects of different boiling conditions on quality of Buyang Huanwu decoction by double decocting non-pressurized machine. Method: A single factor test was adopted to investigate levels of adding water

with the contents of total solids

ferulic acid and astragaloside as comprehensive evaluation index

effects of soaking time

the amount of water

boiling times and time on technology were investigated by orthogonal test.The contents of ferulic acid and astragaloside were determined by HPLC. Result: Analysis of variance showed that effect of factors on boiling technology was in order of decoction times>the amount of water>decoction time>soaking time

only decoction times had significant impact.Optimum non-pressurized boiling technology was as following:soaked 30 min with 8-10 times the amount of water

decoction for 2 times

60 min per time. Conclusion: Optimized technology was stable and feasible

it provided theoretical basis for ferulic acid and astragaloside as main ingredients in traditional Chinese medicine decoctions.

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Related Institution

Tianjin University of Traditional Chinese Medicine

Tianjin Instiute of Pharmaceutical Research

Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine

New Drug Research and Development Center,Guangzhou University of Chinese Medicine

Institute of Material Medica,Key Laboratory of Advanced Drug Delivery of Guangdong Province,Guangdong Pharmaceutical College

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