Objective: To compare in vitro dissolution of geniposide from ultrafine and ordinary powder of mongolian Gardeniae Fructus. Method: The content of geniposide was determined by HPLC

chromatographic conditions were as follows:Elite C18 column(4.6 mm×250 mm

5 μm)

detection wavelength 238 nm

mobile phase of acetonitrile-water (15:85)

flow rate 1.0 mL·min-1

injection volume 20 μL.Dissolution amount and dissolution rate of geniposide from ultrafine and ordinary powder of mongolian Gardeniae Fructus were determined

and in vitro dissolution behavior was analyzed. Result: Dissolution amount of geniposide from ultrafine and ordinary powder of mongolian Gardeniae Fructus were 34.019 and 52.638 mg·g-1

in vitro dissolution curves were in line with Weibull distribution

t50

td

t70

t80 of ordinary powder were 1.501

14.211

70.877 and 2 339.955 min

respectively

but them of ultrafine powder were 1.339

1.505

1.637

1.964 min.Dissolution rate of geniposide from ultrafine powder was higher than common powder

the largest cumulative dissolution of ultrafine powder was raised 30% by comparing with common powder. Conclusion: Superfine grinding could promote dissolution of geniposide in mongolian Gardeniae Fructus

it revealed that application of superfine grinding to deal with mongolian Gardeniae Fructus was feasible.