LV Jia, LIU Bing, ZHANG Zhen-qiu, et al. Preparation of Solid Lipid Nanoparticles Loading Matrine[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(19): 61-63.
DOI:
LV Jia, LIU Bing, ZHANG Zhen-qiu, et al. Preparation of Solid Lipid Nanoparticles Loading Matrine[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(19): 61-63. DOI: 10.11653/syfj2013190061.
Preparation of Solid Lipid Nanoparticles Loading Matrine
Objective: To optimize formulation technology of matrine solid lipid nanoparticles and investigate its appearance and particle size distribution. Method: Matrine solid lipid nanoparticles were prepared ultrasonic dispersion method
with entrapment efficiency of matrine as index
orthogonal test was adopted to investigate effects of ratio of matrine-stearic acid
ratio of stearic acid-soybean lecithin
poloxamer concentration and oil-water phase ratio on formulation technology. Result: Optimum formulation technology was as following:matrine-stearic acid (1:6)
stearic acid-soybean lecithin (1:1)
poloxamer concentration 12 g·L-1
oil phase-water phase (1:5).Prepared matrine solid lipid nanoparticles was emulsion solution with luster
showed ivory white
it may produce white flocculus after shaking
average encapsulation efficiency was 82.8%
average drug loading was 5.5%.These nanoparticles were irregular spherical or ellipsoidal with uniform distribution
average particle size was 155 nm. Conclusion: Optimzed formulation technology was feasible and stable with good application prospects.
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Related Author
Jun-li YAN
Wan-rong LI
Jia-jia YANG
Yi WANG
Zhi-yong HE
Feng JIANG
Xue ZHOU
Lin-jing WU
Related Institution
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Center of Efficient Utilization of Natural Medicine Resources, High Educational Key Laboratory of Natural Medicinal Pharmacology and Druggability of Guizhou Province, Key Laboratory of Optimal Utilization of Natural Medicinal Resources, Guizhou Medical University
Qiannan Medical College for Nationalities
Jilin Natural Pharmaceutical Research and Development Co.Ltd.