Objective: To explore different effects in Epimedii Folium processed pieces which processed by different quality oils from Capra hircus L. or Ovis aries L. on kidney-yang deficiency syndrome mice. Method: The kidney Yang deficiency syndrome mice model was established that mice were intramuscular injected (im) large dose of hydrocortisone. Crude drug and 6 kinds of pieces processed by different quality of oils

such as oil from C. hircus or O. aries

oil in abdominal or tail

oil from rams or ewes

were used as test group. The total flavonoids of Epimedium folium was used as positive control. Negative control group and model control group were also applied in the lab. The models were created and at the same time drugs were administered. The same volume normal saline(NS) was given to negative control group and model control group by ig administration. The concentration of total flavonoid extracts was 0.46 g·kg-1 and the content of total flavonoid was 0.23 g·kg-1. The extracts were given to positive control group. Doses were given to test groups were 18 g·kg-1

which equivalent to the crude drug. Dosing volume was 15 mL·kg-1 for each group. Administration was one time a day for 9 days

successively. The signs and symptoms of kidney Yang deficiency mice

such as weight

temperature of animal 's surface

number of independent activities

were used as index. Animal holding power

clotting time

contents of superoxide dismutase(SOD) and malondialdehyde(MDA) in serum were also used. The difference of effects between different samples on kidney Yang deficiency syndrome in mice were studied. Result: It was decreasing significantly for the weight

temperature of animal's surface

number of independent activities

contents of SOD and MDA in serum in model control group in contrast with negative control group and the difference was statistically(P<0.01

in all). It was decreasing for the trend of animal holding power and clotting time. That means the model is successful. The test group can inhibit the decrease of weight

except the pieces processed by oil from C. hircus in contrast with model control group. The test group can increase the temperature and the number of activities

and all the difference were statistically(P<0.01or P<0.05). The test group can increase the content of SOD and decrease the content of MDA

especially for the pieces processed by oils from C. hircus and from O. aries

oil in abdominal and in tail. There was statistical significance (P<0.01 or P<0.05). Otherwise

it was increase for the trend of holding power

but there was no statistical significance. It had the trend to extend clotting time only in the test group of pieces processed by oil from O. aries. The weak condition of kidney Yang deficiency syndrome in mice(including Yang) have been strongly improved by the processed pieces according in contrast with the crude drug. There are no significant difference between the processed pieces. Conclusion: The effect of processed pieces group is super to crude drug. The efficacy can be affected by the different quality of oils from C. hircus or O. aries

but there is no statistical significance.