Effect of Banana Peel Polyphenol on Blood Lipid and Antioxidant Capability in Hyperlipidemia Rats

ZHU Kai-mei; ZHAO Wen-peng; ZHAO Lei; LUO Cai-zhen; GU Sheng-jiu

doi:10.11653/syfj2013190213

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Effect of Banana Peel Polyphenol on Blood Lipid and Antioxidant Capability in Hyperlipidemia Rats

更新时间：2024-01-04

- Effect of Banana Peel Polyphenol on Blood Lipid and Antioxidant Capability in Hyperlipidemia Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 19, Pages: 213-216(2013)
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- DOI：10.11653/syfj2013190213
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- Published：2013
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ZHU Kai-mei, ZHAO Wen-peng, ZHAO Lei, et al. Effect of Banana Peel Polyphenol on Blood Lipid and Antioxidant Capability in Hyperlipidemia Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(19): 213-216.
DOI：

ZHU Kai-mei, ZHAO Wen-peng, ZHAO Lei, et al. Effect of Banana Peel Polyphenol on Blood Lipid and Antioxidant Capability in Hyperlipidemia Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(19): 213-216. DOI： 10.11653/syfj2013190213.

摘要

目的: 以高脂血症大鼠为模型比较香蕉皮多酚、辛伐他汀降血脂及抗氧化作用。方法: 60只大鼠随机分为6组

每组10只

即对照组、模型组、阳性药辛伐他汀组(10 mg·kg-1)、香蕉皮多酚低、中、高剂量组(30

120 mg·kg-1)。正常对照组喂食普通饲料

其余5组每天灌胃给予高脂饲料制备高脂血症大鼠模型

造模的同时给予香蕉皮多酚干预

连续给药40 d后测定总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙二醛(MDA) 的含量

超氧化物歧化酶(SOD) 的活性。结果: 与正常对照组比较

模型组大鼠血清中TG

LDL-C

MDA含量显著升高(P<0.05)

而血清HDL-C

SOD

T-AOC活性显著降低(P<0.05);与模型组比较

香蕉皮多酚低、中、高剂量组大鼠血清TG

LDL-C

MDA 均有不同程度降低(P<0.05)

血清HDL-C

SOD和T-AOC的活性显著升高(P<0.05)。结论: 香蕉皮多酚对高脂血症模型大鼠具有降低血脂及抗氧化的双重作用。

Abstract

Objective: To compare the antihyperlipidemic and antioxidative effect of banana peel polyphenol and simvastatin. Method: Sixty rats were randomly divided into 6 groups

control group

model group

positive drug simvastatin group (10 mg·kg-1)

banana peel polyphenol low

middle and high dose group

(30

120 mg·kg-1)

10 rats in each group. Control group were fed with common food

the remaining 5 groups were intragastrically given high fat diet

banana peel polyphenol was administrated at the same timefor 40 days. Then the content of cholesterol(TC)

triglyceride(TG)

high density lipoprotein-cholesterol(HDL-C)

low density lipoprotein-cholesterol(LDL-C)

malondialdehyde(MDA) and the activity of the super oxide dismutase (SOD) in serum were determined. Result: Compared with the normal control group

the rats in the model group

serum TG

LDL-C

MDA were significantly increased (P<0.05)

but the serum HDL-C

SOD

T-AOC activity was significantly decreased (P<0.05); compared with the model group

the banana peel polyphenols of low

middle and high dose group

serum TG

LDL-C

MDA were decreased in different degree (P<0.05)

serum HDL-C

SOD and the activity of T-AOC increased significantly (P<0.05). Conclusion: Banana peel polyphenol has antihyperlipidemic and antioxidative effects on hyperlipidemic model rats.

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