Objective: To discuss protective effect of polygala fallax in radiation injured mice. Method: Polygala fallax extract was given at dose of 2

4

8 g·kg-1·d-1 respectively

negative control group add equivalent normal saline as control group. After 5 days of administration

in addition to the negative control group. micereceived disposable irradiate 6 Gy of 60Co γ radiation uniformly

administration lasted 10 days. 24 h after end administration

red blood cell count (RBC)

white blood cell count (WBC)

platelet count (PLT)

lymphocytes (Lymph)

spleen index and thymus index

DNA damage of spleen cells and marrow cells were observed. Result: Compared with the negative control group

P. fallax decreased RBC

WBC

PLT

lymph thymus index

spleen index (P<0.01 or P<0.05)

and increased spleen cells in bone marrow cells percentage of tail DNA and tail moment significantly(P<0.01 or P<0.05).But compared with the control group

P. fallax increased RBC count WBC PLT

Lymph thymus index

spleen index significantly(P<0.01 or P<0.05)

and decreased spleen cells in bone marrow cells percentage of tail DNA and Tail Moment significantly(P<0.01). There is dose-response relationship. Conclusion: P. fallax extract have certain protective effect on hemopoietic system and immune organs in mice caused by radiation injury.