Objective: To study the effects of Fructus cnidii on the content of testosterone

substance metabolism and anti-fatigue ability of rats. Method: By using the model of high-intensity endurance training

80 male Wistar rats were divided into 5 groups

15 in each group (the rats which did not meet the requirement were removed):control group (C group)

motion control group (T group)

exercise+ig low-dose F. cnidii group (TML group)

exercise+ig middle-dose F. cnidii group (TMM group)

and exercise+ig high-dose F. cnidii group (TMH group). Gavage was performed using professional device once a day. The rats in F. cnidii groups were treated with 0.75

1.5

4.5 g·kg-1. The rats in C and T groups were given saline of same volume. After 42 days of exhaustive swimming training

body weight

swimming time and serum testosterone and other biochemical markers were measured. Result: The body weight of the rats in F. cnidii groups increased compared with T group (P<0.05)

and the swimming time was longer than T group (P<0.01)

serum corticosterone was lower than the T group (P<0.05)

changes in the ratio of serum testosterone/corticosterone were more consistent with testosterone changes among the groups. Liver glycogen (P<0.05)

muscle glycogen(P<0.01) and hemoglobin(P<0.05) in F. cnidii group were higher than in T group

but the serum urea nitrogen was lower than the T group (P<0.05). Conclusion: F. cnidii can alleviate the impact of high-intensity exercise on serum testosterone

and maintain it at normal physiological levels; it can also promote protein synthesis

inhibit degradation of amino acid and protein

and increase hemoglobin and glycogen reserves in rats exercise training.