Anti-inflammatory and Anti-bacterial Activities of Extractsfrom Extract in Animal Models

XING Wen-shan; LI Yan-hua; ZHU Yu-hua; WANG Qiu-xiang

doi:10.11653/syfj2013190267

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Anti-inflammatory and Anti-bacterial Activities of Extractsfrom Extract in Animal Models

更新时间：2024-01-04

- Anti-inflammatory and Anti-bacterial Activities of Extractsfrom Extract in Animal Models
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 19, Pages: 267-270(2013)
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- DOI：10.11653/syfj2013190267
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- Published：2013
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XING Wen-shan, LI Yan-hua, ZHU Yu-hua, et al. Anti-inflammatory and Anti-bacterial Activities of Extractsfrom Extract in Animal Models[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(19): 267-270.
DOI：

XING Wen-shan, LI Yan-hua, ZHU Yu-hua, et al. Anti-inflammatory and Anti-bacterial Activities of Extractsfrom Extract in Animal Models[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(19): 267-270. DOI： 10.11653/syfj2013190267.

摘要

目的: 选择玉叶金花提取液对动物模型进行抗炎、抑菌作用研究分析。方法: 将小鼠随机分为对照组、阳性对照组和玉叶金花提取液高、中、低剂量组(24

6 g·kg-1)灌胃给药

采用二甲苯致小鼠耳廓肿胀、棉球肉芽肿、角叉菜胶致大鼠足跖肿胀等炎症模型

以及体外抑菌实验

评价玉叶金花提取液的抗炎、抑菌作用。结果: 玉叶金花提取液明显抑制小鼠耳廓肿胀(P<0.05)、大鼠棉球肉芽肿以及大鼠足跖肿胀的形成(P<0.05);玉叶金花提取液对多种致病菌均有明显的抑制作用(P<0.05)。其半数抑菌浓度(MIC50)金黄色葡萄球菌0.95 μg·mL-1、大肠埃希菌0.75 μg·mL-1、肺炎球菌0.65 μg·mL-1、链球菌0.50 μg·mL-1、痢疾杆菌0.25 μg·mL-1。结论: 玉叶金花提取液对急慢性炎症有明显的抑制及体外抑菌作用。

Abstract

Objective: To select Mussaenda extract on animal models of inflammatory

antibacterial research and analysis. Method: The mice were randomly divided into control group

positive control group and M.parviflora extract high

medium and low dose group (24

6 g·kg-1) administered orally

using xylene-induced mouse ear profile swelling

granuloma; carrageenan-induced rat paw edema inflammation model

and antibacterial experiments in vitro evaluation M. parviflora extract anti-inflammatory

effect. Result: M. parviflora extract significantly inhibited mouse ear edema(P<0.05)

as well as rat granuloma rat paw edema formation(P<0.05); M. parviflora extract on a variety of pathogenic bacteria were inhibited(P<0.05)

the minimum inhibitory concentration (MIC50) Staphylococcus aureus 0.95 μg·mL-1

E. coli 0.75 μg·mL-1

pneumococcal 0.65 μg·mL-1

Streptococcus 0.50 μg·mL-1

Shigella 0.25 μg·mL-1. Conclusion: M.parviflora extract on acute and chronic inflammation and in vitro inhibition significantly inhibitory effect.

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Related Institution

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