Objective: To explore the pharmacologic activity of Qisun-Demige-Four capsules (QD-4) by animal experiments. Method: The hyperlipidemia and atherosclerosis model of New Zealand rabbits and the obesity model of SD rats were induced by feeding with high-cholesterol diets or high-nutrition diets

the experimental animals were divided into three drug groups which were fed with QD-4(the doses of rabbits were 0.75

0.37

0.19 g·kg-1

and the doses of rats were 3.24

1.62

0.81 g·kg-1)

model group

positive drug group (Simvastatin or Linoleic acid 0.5 mg·kg-1 or 0.39 mg·kg-1) and normal group. The concentrations of total cholesterol (TC)

triglycerides (TG)

low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in the serums and obesity indicators were detected

while aortic atherosclerotic plaque were observed and analyzed to evaluate the effect of QD-4. Result: Compared with the nutritional obese model rats

QD-4 significantly decreased TC(P<0.01)

obviously increased HDL-C(P<0.05)

reduced body weight(P<0.01)

shortened body length

increased tail length of SD rats(P<0.01)

and inhibited the growth of fat cells (the number of cells in unit horizon was increased

P<0.01)

at the same time

the strength of role were better than linoleic acid. However

the food intake of each group of animals had no significantly difference(P<0.01)

TC and HDL-C in QD-4 groups were less than those in linoleic acid group. Compared with the hyperlipidemia and atherosclerosis model of rabbits

QD-4 significantly decreased TC

LDL-C(P<0.01

P<0.05)

reduce the lesions of atherosclerotic rabbit

in accordance with the effects of Simvastatin. Other indexes showed no statistical significance. The experimental results showed that there were obvious dose-effect relationship and the low-dose QD-4 group didn't show significant effect. Conclusion: Mongolian medicine QD-4 can adjust the disorder of lipid metabolism

reduce body weight and inhibit scleratheroma. Results correspond to Mongolian theory about clean and decreasing dirty

reduce 'Badagan'.