Objective: To investigate the protective effects of Tangshenqi on diabetic nephropathy(DN) in rats. Method: The DN model was built by intravenous injection of streptozotocin(STZ) once in sprague dawley(SD)rats.The model rats were randomly divided into six groups:model control group

high-dosage Tangshenqi group(crude drug

28.0 g·kg-1)

middle-dosage Tangshenqi group(crude drug

14.0 g·kg-1)

low-dosage Tangshenqi group(crude drug

7.0 g·kg-1)

Tangmaikang granule group

and gliquidone+captopril group. The rats were continuously administrated for 12 weeks

in the same time

the general situations in rats were observed

and body weight

food intake

water intake

urine index(urine sugar and urine protein)

blood index(fasting glucose

creatinine

urea

glycosylated hemoglobin)were regularly tested. After the last administration

kidney weight

kidney index

and area of glomerular positive region by PAS staining were measured

while the examination of kidney histopathology was carried out. Result: Tangshenqi could reduce blood glucose in DN rats

regulate abnormal glucose metabolism

and promote the transformation of hepatic glycogen.It could also reduce uriinary volume

as well as the content of urine sugar and urine protein

and increase glomerular filtration rate. Moreover it could inhibit kidney hypertrophy

reduce incidence of kidney disease

as well as improve and repair the degree of lesions. Conclusion: Tangshenqi could have a good protective effect on diabetic nephropathy (DN) in rats.