Objective: To investigate the therapeutic effect of Feiwei granules combined with large doses of N-acetyl cysteine on plmonary fibrosis. Method: One hundred and thirty patients with plmonary fibrosis were chose during the period from February 2010 to February 2012 in our hospital and randomly divided into two groups including control group (65 patients) with conventional hormone therapy and observation group (65 patients) with Feiwei granules combined with large doses of N-acetyl cysteine; and the clinical total effective rate

positive rate of change for chest high-resolution CT (HRCT)

before and after treatment symptom scores of traditional Chinese medicine(TCM) and lung function index of both groups were compared. Result: The clinical total effective rate of observation group was significantly higher than control group(P<0.05). The positive rate of change for chest high-resolution CT (HRCT) including grid shadow and patches shadow of observation group were significantly lower than control group(P<0.05). The symptom scores of TCM after treatment in both groups were significantly better than before treatment

and the symptom scores of TCM after treatment of observation group were significantly better than control group(P<0.05). The lung function index including total lung capacity(TLC) and forced vital capacity(FVC) of observation group were significantly better than control group(P<0.05). Conclusion: Compared with conventional hormone therapy

Feiwei Granules combined with large doses of N-acetyl cysteine can efficiently improve clinical symptoms and lung function

and is worthy of clinical application value.