Extraction Technology Change and Pharmacological Test Verification of Tongmai Oral Liquid

YANG Feng-mei; XIONG Yong-ai; HOU Li-wei; HUANG Jing; WANG Nian-ming; YANG Ming

doi:10.11653/syfj2013200032

您当前的位置：

首页 >

文章列表页 >

Extraction Technology Change and Pharmacological Test Verification of Tongmai Oral Liquid

更新时间：2024-01-04

- Extraction Technology Change and Pharmacological Test Verification of Tongmai Oral Liquid
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 20, Pages: 32-35(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013200032
  CLC：
- Published：2013
- 稿件说明：
移动端阅览
YANG Feng-mei, XIONG Yong-ai, HOU Li-wei, et al. Extraction Technology Change and Pharmacological Test Verification of Tongmai Oral Liquid[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(20): 32-35.
DOI：

YANG Feng-mei, XIONG Yong-ai, HOU Li-wei, et al. Extraction Technology Change and Pharmacological Test Verification of Tongmai Oral Liquid[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(20): 32-35. DOI： 10.11653/syfj2013200032.

摘要

目的: 比较不同提取工艺制备的通脉提取液对实验性小鼠心肌缺血的影响。方法: 采用腹腔注射异丙肾上腺素建立小鼠心肌缺血模型

比较不同提取工艺制备的通脉提取液A和通脉提取液B、市售通脉口服液、复方丹参片不同药物对小鼠血浆ATP含量、心肌组织的影响。结果: 模型对照组、通脉口服液组、通脉提取液A组、通脉提取液B组、复方丹参片组、空白正常组血浆中ATP质量浓度分别为(197.06±77.78)

(239.60±60.90)

(328.21±84.27)

(318.42±70.87)

(271.13±66.45)

(475.93±94.98) μg·L-1

心肌组织损伤指数分别为(2.26±0.86)

(1.16±0.28)

(0.59±0.17)

(0.76±0.23)

(0.68±0.12)

0。通脉提取液A和通脉提取液B均表现出比通脉口服液更为显著的治疗效果

治疗效果优于复方丹参片

且通脉提取液A效果略优于通脉提取液B。结论: 变更工艺后制备的通脉提取液A和B均可显著改善小鼠心脏缺血

提高心功能

治疗效果明显优于市售通脉口服液

其中通脉提取液A作用更显著。

Abstract

Objective: To compare effects of different extraction processes for Tongmai oral liquid on experimental myocardial ischemia in mice. Method: Intraperitoneal injection of isoproterenol in mice to establish model of myocardial ischemia.Effects of Tongmai extract A

Tongmai extract B

commercially available Tongmai oral liquid and compound Danshen tablets on plasmic ATP content and myocardial tissue in mice were compared. Result: The concentration of plasmic ATP in model group

Tongmai oral liquid group

Tongmai extract A group

Tongmai extract B group

compound Danshen tablets group and blank control group were (197.06±77.78)

(239.60±60.90)

(328.21±84.27)

(318.42±70.87)

(271.13±66.45)

(475.93±94.98) μg·L-1

respectively;Myocardial tissue damage index of these groups were (2.26±0.86)

(1.16±0.28)

(0.59±0.17)

(0.76±0.23)

(0.68±0.12)

respectively.Treatment effect of Tongmai extract A and Tongmai extract B were significantly better than Tongmai oral liquid and better than compound Danshen tablets without significantly influence

but Tongmai extract A was slightly better than Tongmai extract B. Conclusion: After changing of extraction processes

Tongmai extract A and Tongmai extract B could significantly improve myocardial ischemia in mice by increasing heart function

treatment effect was significantly better than commercially available Tongmai oral liquid

wherein Tongmai extraction A showed more significant role.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

LC-MS-Based Metabonomics Study of Yangxin Tongmaifang Against Coronary Heart Disease Differentiated into Blood Stasis Syndrome

Protective Effect of Qiqilian Capsule Against Left Ventricular Hypertrophy of Spontaneously Hypertensive Rats

Determination of Contents of Adenine Nucleotides and Energy Charge in Rat Liver Tissue Treated with Aconite Roots by HPLC

Related Author

Yun-feng YU

Xiao-xin LUO

Xia-hui ZHOU

Yi-fan ZHANG

Yan-zhen ZHAO

Wei-xiong JIAN

Man-li ZHOU

WANG Xiao-ping

Related Institution

College of Traditional Chinese Medicine（TCM），Hunan University of Chinese Medicine

Provincial Key Laboratory of TCM Diagnostics，Key Laboratory of TCM Heart and Lung Syndrome Differentiation ＆ Medicated Diet and Dietotherapy，Hunan University of Chinese Medicine

Shandong University of Traditional Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰