Study on the Effect of  Cortex on Diabetic Retinopathy and the Mechanism

YUE Li-jun; ZHANG Yan; XIANG Li; LAI Xian-rong; MENG Xian-li

doi:10.11653/syfj2013200149

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Study on the Effect of Cortex on Diabetic Retinopathy and the Mechanism

更新时间：2024-01-04

- Study on the Effect of Cortex on Diabetic Retinopathy and the Mechanism
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 20, Pages: 149-153(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013200149
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- Published：2013
- 稿件说明：
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YUE Li-jun, ZHANG Yan, XIANG Li, et al. Study on the Effect of Cortex on Diabetic Retinopathy and the Mechanism[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(20): 149-153.
DOI：

YUE Li-jun, ZHANG Yan, XIANG Li, et al. Study on the Effect of Cortex on Diabetic Retinopathy and the Mechanism[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(20): 149-153. DOI： 10.11653/syfj2013200149.

摘要

目的: 研究藏药吉尔巴对糖尿病视网膜病变模型(DR)大鼠的降血糖作用、抗氧化应激作用、血管保护作用及其相关机制。方法: SD大鼠单次ip给予链脲佐菌素(STZ)40 mg·kg-1制备2型糖尿病模型

高脂饲料喂养5个月

随机分组

给予相应药物

连续30 d

实验期间监测大鼠体质量、血糖的变化

实验结束后检测大鼠超氧化物歧化酶(SOD)活力

一氧化氮(NO)、丙二醛(MDA)、细胞黏附分子(ICAM-1)、血管紧张素Ⅱ(ANGⅡ)的水平

并通过大鼠视网膜HE染色分析其病理变化。结果: 吉尔巴浸膏可显著降低DR模型大鼠空腹血糖

可减轻视网膜病理改变

降低大鼠视网膜内皮细胞/周细胞值(E/P)

显著增强SOD活力

降低血清细胞黏附分子(ICAM-1)和血管紧张素Ⅱ(ANGⅡ)含量。结论: 吉尔巴浸膏能够减轻糖尿病视网膜病变程度

减缓发展进程

同时具有整体调节功能

对糖尿病大鼠视网膜具有保护作用。

Abstract

Objective: To evaluate the hypoglycemiceffect of extract from Tibetan medicine Berberis dictyophlla Cortex on postprandial blood glucose (PBG)

protection against oxidative stress

protection function on blood vessels in diabetic rats induced by streptozotocin(STZ)and to explore the mechanism. Method: The type 2 diabetic rat model was established by ip injection of STZ (40 mg·kg-1) on SD rats and the rats were fed with high sugar and high fat for 5 months.Then

the rats were divided into 8 groups and administered. During the experiment

the body weight

fasting blood glucose (FBG) were measured. After 30 days of administration

the superoxide dismutase (SOD)

malondialdehyde (MDA)

nitric oxide(NO)

cell adhesion molecule(ICAM-1)

angiotensin(ANGⅡ)

and other blood biochemical indexes were measured. Result: The B. dictyophlla cortex could reduce significantly the level of fasting blood glucose

ICAM-1 and ANGⅡexpression. The retinas were taken and observed by histopathological analysis

the tissue injury attenuated compared with the model group. The contents of SOD in serum of group were higher while MDA was lower than the model group. Conclusion: DR of B. dictyophlla cortex group was obviously better compared with the model group. The extract of B. dictyophlla cortex can improve effectively retinopathy of the rats

relieve the degree and development of DR and regulate function in the whole. All in all

Berberis Cortex showed the effect of prevention and therapy of DR.

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WANG Kai-fu

Related Institution

Guang'anmen Hospital， China Academy of Chinese Medical Sciences

Xiyuan Hospital， China Academy of Chinese Medical Sciences

Beijing University of Chinese Medicine

Wangjing Hospital of China Academy of Chinese Medical Sciences

Hebei University of Chinese Medicine

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