Impact of Mangankang Pill on Cellular Immune Function to Patients with Liver Stagnation and Spleen Deficiency Syndrome in Chronic Hepatitis B

LIU Jiang-kai; ZHAO Wen-xia; WANG Xiao; ZHANG Yan-fang

doi:10.11653/syfj2013200293

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Impact of Mangankang Pill on Cellular Immune Function to Patients with Liver Stagnation and Spleen Deficiency Syndrome in Chronic Hepatitis B

更新时间：2024-01-04

- Impact of Mangankang Pill on Cellular Immune Function to Patients with Liver Stagnation and Spleen Deficiency Syndrome in Chronic Hepatitis B
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 20, Pages: 293-296(2013)
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- DOI：10.11653/syfj2013200293
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- Published：2013
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LIU Jiang-kai, ZHAO Wen-xia, WANG Xiao, et al. Impact of Mangankang Pill on Cellular Immune Function to Patients with Liver Stagnation and Spleen Deficiency Syndrome in Chronic Hepatitis B[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(20): 293-296.
DOI：

LIU Jiang-kai, ZHAO Wen-xia, WANG Xiao, et al. Impact of Mangankang Pill on Cellular Immune Function to Patients with Liver Stagnation and Spleen Deficiency Syndrome in Chronic Hepatitis B[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(20): 293-296. DOI： 10.11653/syfj2013200293.

摘要

目的: 观察慢肝康丸对肝郁脾虚证慢乙肝(CHB)患者细胞免疫功能的影响。方法: 将71例中医辨证属肝郁脾虚证慢性乙肝患者随机分为治疗组和对照组

其中治疗组36例

对照组35例。两组都给予拉米夫定联合阿德福韦酯片抗病毒治疗

治疗组在对照组基础上加用慢肝康丸口服

6 g/次

3次/d

疗程共8周。结果: 治疗前后比较表明

两组在对患者肝区疼痛或不适、纳差、乏力、腹胀症状的改善方面均有一定的效果

但治疗组在改善上述症状方面明显优于对照组(P<0.05);丙氨酸转氨酶(ALT)

天冬氨酸转氨酶(AST)两组间比较差异无统计学意义

在降低乙肝病毒(HBV)-DNA方面

治疗组较对照组为优(P<0.05);治疗组在治疗后CD3+

CD4+升高

CD8+下降

CD4+/CD8+升高

与对照组相比差异有统计学意义(P<0.05)。结论: 慢肝康丸可改善肝郁脾虚证慢乙肝患者细胞免疫紊乱状态

提高抗病毒治疗效果。

Abstract

Objective: Observed the impact of Mangankang pill to the patients with liver stagnation and spleen deficiency syndrome in chronic hepatitis B(CHB) cellular immune function. Method: Seventy-one patients with chronic hepatitis B were enrolled and randomized into two groups:the treated group(36 cases)and the control group(35 cases).The two groups were given lamivudine treatment

the treatment group was given Mangankang pill

6 g/times

3 times/day

with a course of eight weeks. Result: The two groups can improve liver pain or discomfort

anorexia

fatigue

bloating symptoms

the treatment group better than the control group(P<0.05).No significant difference between the two groups in the improvement of alanine aminotrans ferase(ALT) and aspartate aminotrans ferase(AST).The treatment group was more significant in the reduction of hepatitis B virus(HBV)-DNA (P<0.05).Treatment group CD3+

CD4+ increased

CD8 decreased

CD4+/CD8+ increased after treatment.Differencebwas statistically significant compared with the controlngroup(P<0.05). Conclusion: Mangankang pill can improve the status of liver stagnation and spleen deficiency syndrome in patients with chronic hepatitis B-free cellular immune disorders

improve the therapeutic effect of anti-viral.

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