Effect of Bailing Capsule on T Lymphocyte Subsets in Patients with Graves’ Disease

HUANG Hong; YANG Pi-jian; LI Shu-min; LV Yi-pei; HUANG Zhong-ying

doi:10.11653/syfj2013200296

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Effect of Bailing Capsule on T Lymphocyte Subsets in Patients with Graves’ Disease

更新时间：2024-01-04

- Effect of Bailing Capsule on T Lymphocyte Subsets in Patients with Graves’ Disease
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 20, Pages: 296-299(2013)
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- DOI：10.11653/syfj2013200296
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- Published：2013
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HUANG Hong, YANG Pi-jian, LI Shu-min, et al. Effect of Bailing Capsule on T Lymphocyte Subsets in Patients with Graves’ Disease[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(20): 296-299.
DOI：

HUANG Hong, YANG Pi-jian, LI Shu-min, et al. Effect of Bailing Capsule on T Lymphocyte Subsets in Patients with Graves’ Disease[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(20): 296-299. DOI： 10.11653/syfj2013200296.

摘要

目的: 探讨观察百令胶囊对Graves 病(Graves' disease

GD) 患者T淋巴细胞亚群及远期预后的影响。方法: 选择GD患者60例

分为常规治疗组、百令胶囊治疗组

每组30例

常规治疗组予甲巯咪唑治疗

百令胶囊治疗组在常规治疗组治疗的基础上加用百令胶囊

4粒/次

3次/日

连续用药12个月

观察两组治疗前后外周血T淋巴细胞亚群、甲状腺功能、干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)、自身抗体变化

停药后随访1年

观察GD复发率。结果: 治疗结束时两组甲状腺功能差异不显著

百令胶囊治疗组治疗后外周血CD4+

CD4/CD8

IFN-γ

促甲状腺激素受体抗体(TRAb)[CD4+(30.6±2.1)%

CD4/CD8(1.5±1.7)

IFN-γ(25.8±4.2) μg·L-1

TRAb(18.2±10.6)U·L-1]·L-1

TRAb(18.2±10.6)U·L-1]较常规治疗组[(35.9±1.8)%

(1.7±1.3)

(34.8±2.4)μg·L-1

(25.9±8.8)U·L-1]·L-1

(25.9±8.8)U·L-1]下降更明显

且差异有统计学意义(P<0.05)

CD8+T细胞亚群数、IL-4水平升高更明显[CD8+(23.1±1.8)% vs (20.2±1.3)%

IL-4(14.8±3.2) μg·L-1 vs (12.5±1.7) μg·L-1]·L-1 vs (12.5±1.7) μg·L-1]

且差异有统计学意义(P<0.05);停药1年后随访

百令胶囊治疗组16.7%

较常规治疗组40%复发率明显降低

差异有显著性意义(P<0.05)。结论: 百令胶囊能有效的调节GD患者细胞免疫

降低GD患者自身抗体水平。

Abstract

Objective: To investigate the effect of Bailing capsule on T lymphocyte subsets in patients with Graves' disease(GD). Method: Sixty patients with GD were selected and randomly divided into 2 groups

routine group (n=30) was treated with Methimazole;the Bailing capsule group (n=30) was treated with Bailing capsule(4# Tid)combined with Methimazole. The levels of T-lymphocyte subsets

free triiodothyronine 3(FT3)

FT4

sensitive thyroid stimulating hormone(sTSH)

thyrotrophin receptor antibody(TRAb)

interferon-γ(FN-γ)

interleukin-4(IL-4) were measured in two group pre and post treatment.Follow-up 1 year after treatment

observe the recurrence rate of GD. Result: The thyroid function of the two groups was not significant after treatment. After treatment the CD4+T cells

CD4/CD8

IFN-γ

TRAb in the Bailing Capsule group [CD4+(30.6±2.1)%

CD4/CD8(1.5±1.7)

IFN-γ(25.8±4.2)μg·L-1

TRAb(18.2±10.6)U·L-1] was decreased more significantly than routine group[(35.9±1.8)%

(1.7±1.3)

(34.8±2.4)μg·L-1

(25.9±8.8)U·L-1]. After treatment the CD8+T cells and IL-4 in the Bailing capsule group was increased more significantly than routine group[CD8+(23.1±1.8)% vs (20.2±1.3)%

IL-4(14.8±3.2) μg·L-1 vs(12.5±1.7) μg·L-1] (P<0.05). Follow-up 1 year after withdrawal

the Bailing capsule group than the c routine group recurrence rate was significantly lower(16.7% VS40%)(P<0.05). Conclusion: The Bailing capsule can effectively regulate the GD patient's cellular immunity and reduce autoantibody levels in GD patients.

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