CHEN Li-hong, TANG Yu-ping, BIAN Yong, et al. Metabolites Analysis of Puerarin in Rats Model with Syndrome of Dampness-Heat in Large Intestine[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(21): 167-169.
DOI:
CHEN Li-hong, TANG Yu-ping, BIAN Yong, et al. Metabolites Analysis of Puerarin in Rats Model with Syndrome of Dampness-Heat in Large Intestine[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(21): 167-169. DOI: 10.11653/syfj2013210167.
Metabolites Analysis of Puerarin in Rats Model with Syndrome of Dampness-Heat in Large Intestine
Objective: To analyze metabolites of puerarin in rats model with syndrome of dampness-heat in large intestine. Method: Rats model with syndrome of dampness-heat in large intestine was established
metabolites of puerarin in urine from model rats with syndrome of dampness-heat in large intestine were analyzed by UPLC-DAD-MS. Result: Eight components were identified as isomer of puerarin-O-glucuronide
puerarin-O-glucuronide
puerarin
daidzein-O-glucuronide
methyldaidzein-O-glucoside
isomer of methyldaidzein-O-glucuronide
methyldaidzein
methyldaidzein-O-glucuronide. Conclusion: Puerarin was excreted in the form of two-phase metabolites with glucuronide conjugate and glucoside conjugate
methylated metabolite as well as prototype in urine of model rats with syndrome of dampness-heat in large intestine.
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