Influence of Qisang Jiangtang Fang on Blood Glucose and Serum Lipoprotein Metabolism in Rats with Experimental Type 2 Diabetes

TIAN Chun-yu; BO Hai-mei; BAI Jing; LI Ji-an; LA Xiao-jin; QI Feng; WU Fan-wu; ZHAO Shu; ZHU Liang

doi:10.11653/syfj2013210207

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Influence of Qisang Jiangtang Fang on Blood Glucose and Serum Lipoprotein Metabolism in Rats with Experimental Type 2 Diabetes

更新时间：2024-01-04

- Influence of Qisang Jiangtang Fang on Blood Glucose and Serum Lipoprotein Metabolism in Rats with Experimental Type 2 Diabetes
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 21, Pages: 207-209(2013)
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- DOI：10.11653/syfj2013210207
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- Published：2013
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TIAN Chun-yu, BO Hai-mei, BAI Jing, et al. Influence of Qisang Jiangtang Fang on Blood Glucose and Serum Lipoprotein Metabolism in Rats with Experimental Type 2 Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(21): 207-209.
DOI：

TIAN Chun-yu, BO Hai-mei, BAI Jing, et al. Influence of Qisang Jiangtang Fang on Blood Glucose and Serum Lipoprotein Metabolism in Rats with Experimental Type 2 Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(21): 207-209. DOI： 10.11653/syfj2013210207.

摘要

目的: 研究芪桑降糖方对实验性2型糖尿病(T2DM)模型大鼠糖代谢及脂代谢的影响。方法: 大鼠高糖高脂饲料喂养4周后

ip 40 mg·kg-1链脲佐菌素(STZ)建立T2DM大鼠模型

随机分为糖尿病模型对照组、芪桑降糖方低剂量组(ig 180 mg·kg-1·d-1)、中剂量组(ig 360 mg·kg-1·d-1)、高剂量组(ig 540 mg·kg-1·d-1)及罗格列酮治疗组(ig 4 mg·kg-1·d-1)。持续ig给药60 d后测空腹血糖(FBG)、血脂、糖化血红蛋白(HbAlc)、胰岛素(Ins)的含量。结果: 与正常组比较

模型组大鼠HbAlc含量显著增高(P<0.01)

总胆固醇(TCH)、血清甘油三酯(TG)、低密度脂蛋白(LDL均明显升高(P<0.05)

高密度脂蛋白(HDL)明显下降(P<0.05)。芪桑降糖方可降低T2DM模型大鼠的FBG、HbAlc、TCH、TG、LDL水平

提高HDL和Ins水平

与模型组比较有明显改善(P<0.05)

芪桑降糖方与罗格列酮药物治疗组无显著性差异。结论: 芪桑降糖方能有效地降低T2DM模型大鼠的血糖

促进Ins分泌

纠正糖尿病大鼠脂代谢紊乱

调节血脂。

Abstract

Objective: To study the influence of Qisang Jiangtang Fang (Q-S) on blood glucose

serum lipoprotein in type 2 diabetes(T2DM) rats. Method: T2DM model was induced with high sucrose-fat diet for 4 weeks and streptozocin (STZ)ip for 40 mg·kg-1

rats were randomly divided into groups:model group

Q-S low dose(ig 180 mg·kg-1·d-1)and middle dose(ig 360 mg·kg-1·d-1)and high dose group(ig 540 mg·kg-1·d-1)

rosiglitazone treatment group(ig 4 mg·kg-1·d-1).Blood glucose

serum lipoprotein

hemoglobin Alc (HbAlc)

insulin (Ins)contents in rats were detected after 60 d of continuous medication. Result: Compared with normal group

HbAlc levels were significantly increased (P<0.01)

total cholesterol (TCH)

total triglyceride (TG)

low density lipoprotein (LDL) were significantly increased (P<0.05)

high density lipoprotein (HDL)decreased significantly (P<0.05) in model group. Q-S can reduce the levels of blood glucose

HbAlc

TCH and LDL

improve the level of HDL and Ins

those were significant deviation compare dwith the model group(P<0.05)

it was no significant difference with the rosiglitazone treatment group. Conclusion: Q-S can effectively reduce rat's blood glucose of T2DM

promote Ins secretion

improve t the disorder of lipid metabolism in diabetic rats

regulate serum lipoprotein.

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