Influence of Isoflovone on Learning and Memory and Monoamine Neuro-transmitter in Ovariectomized Rats

MAI Wen-li; LIU Xing-hai; LIU Liang; LIU Hong; LIU Hua

doi:10.11653/syfj2013210223

您当前的位置：

首页 >

文章列表页 >

Influence of Isoflovone on Learning and Memory and Monoamine Neuro-transmitter in Ovariectomized Rats

更新时间：2024-01-04

- Influence of Isoflovone on Learning and Memory and Monoamine Neuro-transmitter in Ovariectomized Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 21, Pages: 223-226(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013210223
  CLC：
- Published：2013
- 稿件说明：
移动端阅览
MAI Wen-li, LIU Xing-hai, LIU Liang, et al. Influence of Isoflovone on Learning and Memory and Monoamine Neuro-transmitter in Ovariectomized Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(21): 223-226.
DOI：

MAI Wen-li, LIU Xing-hai, LIU Liang, et al. Influence of Isoflovone on Learning and Memory and Monoamine Neuro-transmitter in Ovariectomized Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(21): 223-226. DOI： 10.11653/syfj2013210223.

摘要

目的: 探讨大豆异黄酮(isoflovone

IS)对去卵巢大鼠空间学习记忆和脑内单胺类递质的影响。方法: 选用青年 SD雌性大鼠

去除双侧卵巢造模。随机分为6组

对照组、模型组、苯甲酸雌二醇组、大豆异黄酮低、中、高剂量组。苯甲酸雌二醇组给大鼠苯甲酸雌二醇ip 0.2 mg·kg-1每周1次

IS低、中、高剂量组剂量分别ig给以大豆异黄酮30

120 mg·kg-1·d-1

共3个月。观察各组大鼠Morris水迷宫学习能力

高效液相检测海马内单胺类神经递质

放射免疫法测定下丘脑内促性腺激素释放激素(gonadotropin-releasing hormone

GnRH)的含量。结果: ①与对照组比较

模型组前3 d定位航行学习能力和空间探索能力明显降低(P<0.05);与模型组比较苯甲酸雌二醇组、IS中剂量组前3 d定位航行学习能力和空间探索能力明显提高(P<0.05)。②与对照组比较模型组海马去甲肾上腺素(norepinephrine

NE)

多巴胺(dopamine

DA)

5-羟色胺(5-hydroxytryptamine

5-HT)含量明显降低(P<0.05);与模型组比较IS高剂量组海马NE含量增高(P<0.05);与模型组比较中剂量组和苯甲酸雌二醇组海马DA和5-HT含量明显增高 (P<0.05) ③与对照组比较模型组GnRH含量明显增高(P<0.05);与模型组比较苯甲酸雌二醇组、IS中、高剂量组GnRH含量明显降低 (P<0.05)。结论: 中剂量大豆异黄酮通过提高海马内NE

5-HT含量

降低海马GnRH含量

提高去卵巢大鼠空间学习记忆能力。

Abstract

Objective: To explore the effects and mechanisms of isoflovone(IS) on spatial learning

memory and monoamine neuro-transmitte

gonadotropin-releasing hormone(GnRH) inovariectomized rats. Method: The fifty Sprague-Dawley rats were ovariectomized. Ovariectomized rats were randomly divided into five groups

model group

estradiol benzoate(EB) group

IS low dose group

IS middle dose group

IS high dose group. EB group were treated with estradiol benzoate(0.2 mg·kg-1) by intraperitoneal injection once a week. IS groups were treated with IS(30

120 mg·g-1·d-1) by gavage one time daily. The spatial learning and memory performance were evaluated with Morris watermaze task. The contents of monoamine neuro-transmitter in hippocampus were measured

and GnRH in hypothalamus was measured. Result: ① As compared with control group

the latency period of model group increased significantly(P<0.05).Compared with model group

the latency period of EB group and IS middle dose group decreased significantly(P<0.05).②As compared with control group contents of norepinephrine (NE)

dopamine (DA) and 5-hydroxytryptamine (5-HT) in hippocampus of model group decreased significantly(P<0.05). As compared with model group

contents of NE in hippocampus of IS high dose group increased significantly(P<0.05).As compared with model group

contents of DA and 5-HT in hippocampus of IS middle dose group

EB group increased significantly(P<0.05). ③As compared with control group

contents of GnRH in hypothalamus of model group increased significantly(P<0.05).As compared with model group

contents of GnRH in hypothalamus of IS middle and high dose group

EB group decreased significantly(P<0.05). Conclusion: Isoflovone can improve the ovariectomized rats' impairment of spatial learning and memory by increasing contents of NE

5-HT in hippocampus. Otherwise

isoflovone can decrease contents of GnRH in hypothalamus.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Regulation of Glu Neuro-transmitter System and NR2B by Isoflovone in Ovariectomized Rats Brain

Improved Learning and Memory in Sleep-deprived Mice by Anmeidan via Cellular Autophagy Regulation Through PI3K/Akt/mTOR Signaling Pathway

Mechanism of Anmeidan in Improving Learning and Memory in Insomnia Model Rats by Mediating Immunoinflammation via cGAS/STING Signaling Pathway

Effects of Jiaohong Pills and Its Prescription on Scopolamine-induced Alzheimer's Disease Mice

Effect of Cuscutae Semen on Learning and Memory and N6-methyladenosine Modification in Hippocampus of Offspring of Fear-damaged Pregnant Rats

Related Author

DONG Wen

CHEN Jian-lin

LIU Huizhen

ZHANG Yini

CHEN Yumeng

XIAO Chunfeng

ZHANG Xuesong

WANG Ping

Related Institution

School of Basic Medical Sciences， Hubei University of Chinese Medicine

Hubei Shizhen Laboratory

School of Pharmaceutics， Hubei University of Chinese Medicine

Engineering Research Center of Traditional Chinese Medicine Protection Technology and New Product Development for the Elderly Brain Health， Ministry of Education， Hubei University of Chinese Medicine

School of Traditional Chinese Medicine， Hubei University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰