HUANG Gui-ping, LI Cun-yu, LIU Lan-ping, et al. Screeningof Potent Active Components of Cimicifugae Rhizoma for Treating Hepatitis B Virus[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(21): 231-235.
DOI:
HUANG Gui-ping, LI Cun-yu, LIU Lan-ping, et al. Screeningof Potent Active Components of Cimicifugae Rhizoma for Treating Hepatitis B Virus[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(21): 231-235. DOI: 10.11653/syfj2013210231.
Screeningof Potent Active Components of Cimicifugae Rhizoma for Treating Hepatitis B Virus
Objective: To study the potent active components of Cimicifugae Rhizoma for treating hepatitis B virus(HBV). Method: The total phenolic acid and saponins of Cimicifugae Rhizoma were separated by macroporous resin
HBV DNA
HBsAg and HBeAg were observed to analyze the anti-hepatitis B virus effect of prim-o-glucosylcimifugin
ferulic acid
Cimicifugae Rhizoma aqueous extract solution
Cimicifugae Rhizoma phenolic acid and Cimicifugae Rhizoma saponins. Result: The five groups significantly reduced the concentration of HBsAg and HBeAg. Compared with the blank control group
the total phenolic acid can decrease the HBsAg and HBeAg (P<0.01) and the ferulic acid was the potential active component
Cimicifugae Rhizoma saponins can reduce the HBsAg (P<0.05) but prim-o-glucosylcimifugin have no obvious anti-hepatitis B virus effect. The total phenolic acid of Cimicifugae Rhizoma can remarkably decrease the level of viral core associated-HBV DNA in the cytoplasm. Conclusion: The total phenolic acid of Cimicifugae Rhizoma is the active part to anti-hepatitis B virus effect
and the results provide the basis of screening new drugs for treatment hepatitis B virus.
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