Objective: To observe the neuroprotection effect of Zhongfeng 1 on cerebral infarction caused by acute cerebral ischemia in mice and focal cerebral ischemia in rats. Method: Acute cerebral ischemia model in mice was induced by ligaturing the bilateral carotid arteries and vagus nerve

and breathing duration was observed.Cerebral ischemia and infarction in rats were induced by middle cerebral artery occlusion (MCAO). The effects of Zhongfeng 1 were evaluated in the two models. The different doses of Zhongfeng 1 were administrated before modeling (31.74

15.87

7.94 g·kg-1 and 24.78

12.39

6.20 g·kg-1 respectively for mice and rats). In mice

Zhongfeng 1 was given for 8 days before modeling. In rats

Zhongfeng 1 was given for 3 days before modeling. Nimodipine was used as the positive control. Result: Each dose group of Zhongfeng 1 could prolong the breathing duration in mice with acute cerebral ischemia

and the effect was dose-dependent

but without significant difference among different dose groups. Both Zhongfeng 1 high dose group and middle dose group

compared with the model control group

could significantly reduce the proportion of cerebral focal infarction(P<0.001

P<0.01) and significantly improve symptoms of nerve function injury in rats. Conclusion: Zhongfeng 1 has good pharmacological effects on cerebral ischemia in mice and rats. It can prolong the maintenance of mice breathing

significantly reduce infarction ratio of cerebral ischemia

and improve the symptoms of nerve damage.