Efficacy and Safety of Zhengqing Fengtongning for Ankylosing Spondylitis：a Systematic Reviews

LIANG Shan-hao; LAN Wen-rui; LI Yi-kai

doi:10.11653/syfj2013210323

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Efficacy and Safety of Zhengqing Fengtongning for Ankylosing Spondylitis：a Systematic Reviews

更新时间：2024-01-04

- Efficacy and Safety of Zhengqing Fengtongning for Ankylosing Spondylitis：a Systematic Reviews
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 21, Pages: 323-330(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013210323
  CLC：
- Published：2013
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LIANG Shan-hao, LAN Wen-rui, LI Yi-kai. Efficacy and Safety of Zhengqing Fengtongning for Ankylosing Spondylitis：a Systematic Reviews[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(21): 323-330.
DOI：

LIANG Shan-hao, LAN Wen-rui, LI Yi-kai. Efficacy and Safety of Zhengqing Fengtongning for Ankylosing Spondylitis：a Systematic Reviews[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(21): 323-330. DOI： 10.11653/syfj2013210323.

摘要

目的: 评价正清风痛宁治疗强直性脊柱炎的疗效及安全性。方法: 电子检索英文数据库:PUBMED

EMBASE-ASP

Cochrane Library

OVID

Springer-link;中文数据库:中国知识资源总库(CNKI)、万方学术期刊数据库、维普中文期刊数据库(VIP)、中国生物医学文献服务系统(CBM)等作为资料来源

检索时间均从建库至2013年1月。评价纳入研究的质量

提取数据用Revman 5.1软件进行Meta分析。结果: 共纳入12个随机对照试验

1 112例患者。服用正清风痛宁可提高总有效率[MD=3.07

95%CI(1.88

5.02)]、改善全身痛[MD=-0.43

95%CI(-0.61

-0.24)]、脊柱痛[MD=-0.31

95%CI(-0.44

-0.19)]。局部注射正清风痛宁可提高总有效率[OR=4.10

95%CI(1.73

9.71)]、VAS疼痛评分[MD=-2.84

95%CI(-3.68

-2.00)]。局部注射正清风痛宁的皮肤过敏发生率较高。结论: 正清风痛宁治疗强直性脊柱炎具有一定优势

能提高临床总有效率及缓解疼痛

但仍需高质量的临床研究进一步验证其临床疗效和安全性。

Abstract

Objective: To evaluate the effects and safety of Zhengqing Fengtongning for ankylosing spondylitis.Method: Such database as PUBMED

EMBASE-ASP

Cochrane Library

OVID

Springer-link CNKI

VIP

Wanfang and CBM

ect

were searched from the date of their establishment to January 2013.The quality of included studies was evaluated

and meta-analysis was conducted with RevMan 5.1 software. Result: A total of 12 RCTs involving 1 112 patients were included. Meta-analysis showed that there were significant differences between the Zhengqing Fengtongning and western medicines groups in the effect on improving the total effective[MD=3.07

95%CI(1.88

5.02)]

total body pain[MD=-0.43

95%CI(-0.61

-0.24)]

spinal pain[MD=-0.31

95%CI(-0.44

-0.19)].Zhengqing Fengtongning injection would improved the total effective[OR=4.10

95%CI(1.73

9.71)]

VAS score[MD=-2.84

95%CI(-3.68

-2.00)].Zhengqing Fengtongning injection caused a higher incidence of allergic skin. Conclusion: Use high quality clinical trials to further prove the clinical effects and safety of Zhengqing Fengtongning for ankylosing spondylitis(AS) is necessary promptly.

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Related Author

LIAN Shan-hao

CHEN Ting-rui

RUAN Zhang-deyang

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WANG Bao-xin

LI Ru-yi

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Related Institution

School of Basic Medical Sciences， Guangxi University of Chinese Medicine

Affiliated Hospital of Gansu University of Chinese Medicine

Department of Digestive Medicine， Shuguang Hospital， Shanghai University of Traditional Chinese Medicine

Fangchenggang Municipal Hospital of Traditional Chinese Medicine

Clinical College of Chinese Medicine， Gansu University of Chinese Medicine

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