Objective: To optimize prescription of total glycosides sustained-release tablets of Sanqing Jiangtang decoction

then investigate its in vitro release profile and pharmacokinetics in rabbits. Method: With hydroxypropyl methyl cellulose(HPMC) as matrix material

sustained-release tablets was prepared by wet granulation tableting technique.With cumulative release rates in 1

4

8

12 h as comprehensive evaluation index

orthogonal test was adopted to investigate effects of HPMC amount

microcrystalline cellulose(MCC) consumption and starch-lactose on formulation technology

in vitro release and in vivo pharmacokinetics in rabbits of these prepared sustained-release tablets were determined.HPLC was used to determine the content of baicalin

mobile phase of methanol-0.4% phosphoric acid(pH adjusted to 3.0 by triethylamine

48: 52)

detection wavelength 270 nm. Result: Optimum prescription was the mass fraction of HPMC-K4M 20%

MCC 1%

starch and lactose as filler with dosage ratio of 3: 1

5% PVP ethanol as binders;Cumulative release rate of these prepared sustained-release tablets was>90% in 12 h.In vivo release of baicalin fitted well with single compartment model

tmax

Cmax

AUC of two preparations had significant differences. Conclusion: A good correction of in vitro release and in vivo absorption of total glycosides sustained release tablets prepared as optimized prescription was satisfied

the relative bioavailability significantly increased

which reached requirements of sustained-release formulations.