Objective: To investigate the effects of Zhizi Baipi decoction on rat model with TCM Yang-jaundice syndrome. Method: Rat model with Yang-jaundice syndrome was induced by ig α-naphthyl isothiocyanate (APIT)

along with the hot and humid environment and high-fat and high-carbohydrate diet.Several doses of Zhizi Baipi decoction extract were ig administrated to the models

the daily state of rats was observed. The expressions of alanine aminotransferase(ALT)

aspartate aminotransferase(AST)

total bilirubin(TBIL)

bile acid(TBA)

complement C3

C4

total superoxide dismutase(T-SOD)

malonaldehyde(MDA) were detected and the pathological sections were observed under the light microscope. Result: Compared with model group

moderate dose of Zhizi Baipi decoction group and high dose of Zhizi Baipi decoction group decreased significantly ALT

AST

TBIL

TBA

complement C3

C4 in blood serum(P<0.01)

improved the activity of SOD(P<0.05

P<0.01);moderate dose of Zhizi Baipi decoction group decreased the content of MDA (P<0.05)

they reduced the pathological injury in liver tissues at different levels. Conclusion: Zhizi Baipi decoction has positive effects in treatment of TCM Yang-jaundice

the mechanism may lie in alleviating liver injury

antagonizing free radical injury and preventing inflammatory response.