LIU Ya-li, TANG Ying, YI Jia-li, et al. Experimental Research on PI3K/AKT Expression Mechanisms of Buzhong Yiqi Decoction in Nude Mice Lung Adenocarcinoma Transplantation Tumor[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(22): 232-235.
DOI:
LIU Ya-li, TANG Ying, YI Jia-li, et al. Experimental Research on PI3K/AKT Expression Mechanisms of Buzhong Yiqi Decoction in Nude Mice Lung Adenocarcinoma Transplantation Tumor[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(22): 232-235. DOI: 10.11653/syfj2013220232.
Experimental Research on PI3K/AKT Expression Mechanisms of Buzhong Yiqi Decoction in Nude Mice Lung Adenocarcinoma Transplantation Tumor
Objective: To discuss the effect on lung adenocarcinoma transplantation tumor in nude mice and the influence of phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT)signaling pathway of Buzhong Yiqi decoction. Method: 50 nude mice were randomly divided into 5 groups
intervented respectively after 14 days
put to death and calculating tumor inhibition rate and used immunohistochemical method and real time PCR(RT-PCR) detecting the expression level of PI3K
AKT in transplantation tumor tissue. Result: Conbined group was the strongest inhibition rate of transplanted tumor
compared with other groups
there are statistically significant (P<0.05). The q value of synergistic effect of cisplatin and Buzhong Yiqi decoction was 1.201. PI3K and AKT protein and gene mRNA expression in conbined group were decreased. There are statistically difference among other groups (P<0.05). Conclution: The Buzhong Yiqi decoction combined with cisplatin has synergistic inhibitory effect in Cisplatin resistance tumor.The Buzhong Yiqi decoction can increase cisplatin resistance mechanism throught regulating the gene and protein expression of PI3K and AKT.
Effect of Buzhong Yiqi Tang on Cisplatin Resistance A549/DDP Cells in Nude Mice with Lung Adenocarcinoma
Mechanism of Modified Si Junzitang and Shashen Maidong Tang in Improving Sensitivity of Cisplatin in EGFR-TKI Resistant Lung Adenocarcinoma Cells Based on Aerobic Glycolysis
Effect of Yiqi Yangyin Jiedu Prescription on sPD-L1 in Peripheral Blood of Patients Treated with EGFR-TKIs and Prognosis Analysis
Astragalus Polysaccharides Improve Cisplatin Resistance by Inhibiting EMT of Lung Adenocarcinoma A549/DDP Cells Transplanted into Nude Mice
Effect of Astragalus Polysaccharide on EMT of A549/DDP Lung Adenocarcinoma Xenograft: An Exploration Based on PI3K/Akt Signaling Pathway
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