Influence of Different Parts of  Mill. (COM) on Blood Pressure and Heamb RheologyDarameter in Renal Hypertensive Rats

doi:10.11653/syfj2013220254

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Influence of Different Parts of Mill. (COM) on Blood Pressure and Heamb RheologyDarameter in Renal Hypertensive Rats

更新时间：2024-01-04

- Influence of Different Parts of Mill. (COM) on Blood Pressure and Heamb RheologyDarameter in Renal Hypertensive Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 22, Pages: 254-258(2013)
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- DOI：10.11653/syfj2013220254
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- Published：2013
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Influence of Different Parts of Mill. (COM) on Blood Pressure and Heamb RheologyDarameter in Renal Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(22): 254-258.
DOI：

Influence of Different Parts of Mill. (COM) on Blood Pressure and Heamb RheologyDarameter in Renal Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(22): 254-258. DOI： 10.11653/syfj2013220254.

摘要

目的: 研究榅桲果和叶的不同溶剂提取物对肾性高血压大鼠(RHR)血压及血液流变学指标的影响。方法: 采用两肾一夹法(2K1C)制造肾性高血压大鼠 (RHR) 模型

随机分为11组:假手术组、模型组、榅桲果水提取物高、低剂量组、榅桲果乙醇提取物高、低剂量组、榅桲叶水提取物高、低剂量组、榅桲叶乙醇提取物高、低剂量组(均为160

80 mg·kg-1)、阳性对照药卡托普利组(25 mg·kg-1)

每组10只。连续给药8周

在给药前和给药后每2周利用动物无创血压测试仪测量大鼠的收缩压(SBP)和舒张压(DBP)的变化

末次给药后测定血液流变学指标。结果: 给药8周后

榅桲果和叶各提取物能不同程度降低RHR的收缩压和舒张压(P<0.05)

降低RHR的全血黏度和血浆黏度(P<0.05)

降低红细胞压积(P<0.05)、红细胞聚集指数(P<0.05)和红细胞刚性指数(P<0.05)

升高红细胞变形指数(P<0.05)

醇提物各组作用更加显著。结论: 榅桲具有一定的降血压作用

对血液流变性具有一定影响

且有效成分在乙醇提取物中含量较高。

Abstract

Objective: To investigate the effect of different extracts of Cydonia oblonga Mill. (COM) fruits and leaves on blood pressure and hemorheology in renal hypertensive rats(RHR). Method: Two-kidney

one-clip (2K1C) rat model was established and divided randomly into eleven groups:sham group

model group

low and high dosage of aqueous extracts of COM fruits groups

low and high dosage of ethanol extracts of COM fruits groups

low and high dosage of aqueous extracts of COM leaves groups low and high dosage of ethanol extracts of COM leaves groups(80

160 mg·kg-1) and captopril group (25 mg·kg-1)(n=10

each). The drugs were administered for eight weeks;systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured before administration and every 2 weeks

the changes of hemorheology perameter were examined after the last administration. Result: After treatment for eight weeks

in all groups of COM fruits and leaves extracts the SBP and DBP of RHR were lowered in different degrees(P<0.05)

the whole blood viscosity

plasma viscosity

hematocrit

erythrocyte aggregation index and erythrocyte rigidity index were declined(P<0.05)

the erythrocyte deformability index was elevated(P<0.05). The effects of ethanol extracts groups were better. Conclusion: COM extracts have antihypertensive activity and certain influence on hemorheology perameter

and the active ingredients are higher in ethanol extracts.

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Related Author

WANG Guojun

ZHANG Shimin

JIN Jiao

LIU Ning

LIN Hai

SHI Fudong

CHEN Chun

FENG Yadi

Related Institution

Wangjing Hospital of China Academy of Chinese Medical Sciences

Guang'anmen Hospital， China Academy of Chinese Medical Sciences

Hainan Hospital of Traditional Chinese Medicine

Haikou Affiliated Hospital of Central South University Xiangya School of Mcdicine

Institute of Basic Theory of Chinese Medicine，China Academy of Chinese Medical Sciences

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