Objective: To observe the clinical effect of homemade prescription on henoch-schonlein purpura nephritis (HSPN) and the correlation with immune-regulating mechanism. Method: The 60 cases HSPN were randomly grouped to control group and treatment group

each group for 30 cases. The control groups were only used tripterygium wilfordii glycosides tablet

and the treatment groups were cured together with homemade prescription

and the two groups treatment was 3 months.After 3 months treatment continuously

to observe and compare the urinary protein reversed

the urinary red blood cell reversed

the overall clinical effect and safety before and after treatment;and the level of interlenkin-6 (IL-6)

IL-10

IL-18 and tumor necrosis factor-α(TNF-α) in serum before and after treatment were detected. Result: After 3 months' treatment continuously

the treatment group was better than the control group (only used tripterygium wilfordii glycosides tablet) on the urine protein reversed

the urinary red blood cell reversed

the overall clinical effect

safety

and so on

and there was significant difference(P<0.05 or P<0.01);and the treatment group was better than the control group on the drop degree of IL-6

IL-18 and TNF-α level in serum

as well as the elevated degree of IL-10 level. Conclusion: The clinical effect of homemade prescription on HSPN was positive

and there was no obvious side effects

and it was better than the control group

and it was worthy popularized and applied in pediatric clinic. Its clinical curative effect was closely correlated with the regulating body's immunity and improve body's internal environment.