Efficacy and Safety of Tripterygium for Ankylosing Spondylitis：a Systematic Reviews

LIAN Shan-hao; LAN Wen-rui; CHEN Ting-rui; RUAN Zhang-deyang; CHEN Chao; LI Yi-kai

doi:10.11653/syfj2013220339

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Efficacy and Safety of Tripterygium for Ankylosing Spondylitis：a Systematic Reviews

更新时间：2024-01-04

- Efficacy and Safety of Tripterygium for Ankylosing Spondylitis：a Systematic Reviews
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 22, Pages: 339-345(2013)
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- DOI：10.11653/syfj2013220339
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- Published：2013
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LIAN Shan-hao, LAN Wen-rui, CHEN Ting-rui, et al. Efficacy and Safety of Tripterygium for Ankylosing Spondylitis：a Systematic Reviews[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(22): 339-345.
DOI：

LIAN Shan-hao, LAN Wen-rui, CHEN Ting-rui, et al. Efficacy and Safety of Tripterygium for Ankylosing Spondylitis：a Systematic Reviews[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(22): 339-345. DOI： 10.11653/syfj2013220339.

摘要

目的: 评价雷公藤多苷治疗强直性脊柱炎的疗效及安全性。方法: 电子检索英文数据库:PUBMED、EMBASE-ASP、Cochrane Library、OVID、Springer-link;中文数据库:中国知识资源总库(CNKI)、万方学术期刊数据库、维普中文期刊数据库(VIP)、中国生物医学文献服务系统(CBM)等作为资料来源

检索时间均从建库至2012年12月。评价纳入研究的质量

提取数据用Revman5.1软件进行Meta分析。结果: 共纳入8个随机对照试验

576例患者。所纳入的试验质量普遍较低。合并结果表明

雷公藤多苷在改善枕墙距、胸廓活动度、指地距及降低C反应蛋白方面与中药复方组相当

但后者在总有效率

改善晨僵时间、Schober试验及降低血沉要优于雷公藤多苷。雷公藤多苷可发生的不良事件主要为月经推迟、胃肠道不适、肝功能异常等

临床中应谨慎使用。结论: 雷公藤多苷对强直性脊柱炎治疗的优势不明显

仍需高质量的临床试验研究进一步验证其的临床疗效和安全性。

Abstract

Objective: To evaluate the effects and safety of tripterygium for ankylosing spondylitis(AS). Method: Such database as PUBMED

EMBASE-ASP

Cochrane Library

OVID

Springer-link CNKI

VIP

Wanfang and CBM

ect

were searched from the date of their establishment to December 2012.The quality of included studies was evaluated

and meta-analysis was conducted with RevMan 5.1 software. Result: A total of 8 RCTs involving 576 patients were included. Meta-analysis showed that there were no significant differences between the tripterygium and Chinese herbal compound groups in the effect on improving the chest movement

the Occiput-Wall distance

the Finger-Ground distance and C-reactive protein.The Chinese herbal compound showed more effects in improving the total effective rate

the duration of morning stiffness

the Schober test and reducing C-reactive protein.The tripterygium may cause to postpone to menstrual period

gastrointestinal adverse reactions

liver dysfunction

and so on. Conclusion: Use high quality clinical trials to further prove the clinical effects and safety of tripterygium for AS is necessary promptly.

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Related Institution

School of Basic Medical Sciences， Guangxi University of Chinese Medicine

Affiliated Hospital of Gansu University of Chinese Medicine

Department of Digestive Medicine， Shuguang Hospital， Shanghai University of Traditional Chinese Medicine

Fangchenggang Municipal Hospital of Traditional Chinese Medicine

Clinical College of Chinese Medicine， Gansu University of Chinese Medicine

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