Optimization of Preparation Technology of Tangzhiping granules

LUO Wen-rong; YANG Fu-de; JIN Zhi-sheng

doi:10.11653/syfj2013230011

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Optimization of Preparation Technology of Tangzhiping granules

更新时间：2024-01-04

- Optimization of Preparation Technology of Tangzhiping granules
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 23, Pages: 11-14(2013)
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- DOI：10.11653/syfj2013230011
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- Published：2013
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LUO Wen-rong, YANG Fu-de, JIN Zhi-sheng. Optimization of Preparation Technology of Tangzhiping granules[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 11-14.
DOI：

LUO Wen-rong, YANG Fu-de, JIN Zhi-sheng. Optimization of Preparation Technology of Tangzhiping granules[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 11-14. DOI： 10.11653/syfj2013230011.

摘要

目的: 优选糖脂平颗粒的水提取工艺和成型工艺。方法: 以红芪总多糖含量为考察指标，通过L9（34）正交试验考察加水量、提取时间、提取次数对糖脂平颗粒水提取工艺的影响;以吸湿率、成型性、休止角及制粒情况为考察指标，采用单因素试验考察稀释剂、矫味剂、润湿剂种类及用量对糖脂平颗粒成型工艺的影响。采用固定漏斗法测定休止角。结果: 优选的水提取工艺条件为加10倍量水提取2次，每次2 h。喷雾干燥工艺为喷雾干燥的工艺条件为提取液减压浓缩至相对密度1.05~1.10（60℃），进液物料温度50~60℃，进风口温度170℃，出风口温度85℃;水蛭、僵蚕超微粉碎，丹皮挥发油采用β-CD包合，以91%乙醇为润湿剂，药粉-稀释剂（1∶0.3），矫味剂用量2.0%。结论: 优选的工艺合理可行，适用于糖脂平颗粒的制备。

Abstract

Objective: To optimize water extraction technology and molding process of Tangzhiping granules. Method: With the content of total polysaccharides form Hedysari Radix as index

L9(34) orthogonal test was used to optimize water extraction process of Tangzhiping granules by taking water amount

extraction time and times as factors;With moisture absorption rate

formability

angle of repose and granulation as indexes

single factor tests were adopted to investigate effects of kind and amount of diluents

flavoring agents and wetting agents on molding technology.Angle of repose was determined by fixed funnel method. Result: Optimum water extraction process was as following:extracted 2 times with 10-folds the amount of water

2 h per time.Spray drying process was as following:the relative density of extract 1.05-1.10(60℃)

material temperature 50-60℃

inlet temperature 170℃

outlet temperature 85℃;Ultrafine grinding of Hirudo and Bombyx Batryticatus

volatile oil from Moutan Cortex was prepared β-CD clathrate

with 91% ethanol as wetting agent

powder-diluent(1:0.3)

flavoring agent 2%. Conclusion: Optimized process was reasonable

feasible and applicable to preparation of Tangzhiping granules.

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