Optimization of Machine Decoction Process for Huanglian Jiedu Decoction by Orthogonal Test

JIANG Bin; ZHANG Xing-hai; TANG Liang; SHEN Xi-kun; LI Mei-zhen; HUANG Cheng; ZHU Xiao-yan; WANG Dai-zhu; CAI Bao-chang

doi:10.11653/syfj2013230032

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Optimization of Machine Decoction Process for Huanglian Jiedu Decoction by Orthogonal Test

更新时间：2024-01-04

- Optimization of Machine Decoction Process for Huanglian Jiedu Decoction by Orthogonal Test
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 23, Pages: 32-35(2013)
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- DOI：10.11653/syfj2013230032
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- Published：2013
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JIANG Bin, ZHANG Xing-hai, TANG Liang, et al. Optimization of Machine Decoction Process for Huanglian Jiedu Decoction by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 32-35.
DOI：

JIANG Bin, ZHANG Xing-hai, TANG Liang, et al. Optimization of Machine Decoction Process for Huanglian Jiedu Decoction by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 32-35. DOI： 10.11653/syfj2013230032.

摘要

目的: 优选黄连解毒汤的机器煎煮工艺。方法: 以黄芩苷、小檗碱和浸出物含量的综合评分为指标，通过单因素试验和正交试验考察浸泡时间、煎煮时间、煎煮温度对黄连解毒汤的机器煎煮工艺的影响，并与传统煎煮工艺进行比较。采用HPLC测定指标成分含量，色谱条件为YMC-Pack ODS-A色谱柱（4.6 mm×250 mm，5 μm），流动相甲醇-0.2%磷酸水溶液（47∶53），检测波长250 nm。结果: 黄连解毒汤的最佳机器煎煮工艺为浸泡时间10 min，煎煮温度105℃，煎煮时间30 min，明显优于传统煎煮工艺。结论: 优化的机器煎煮工艺稳定可靠，评价指标可控，为中药汤剂的机器煎煮工艺制定提供实验依据。

Abstract

Objective: To optimize machine decoction process of Huanglian Jiedu decoction. Method: With composite score of baicalin

berberine and extractum contents as index

effects of soak time

decoction time and decoction temperature on machine decoction process were optimized by single factor tests and orthogonal test

and compared with traditional decoction process.Contents of index components were determined by HPLC

chromatographic conditions were as follows:YMC-Pack ODS-A column(4.6 mm×250 mm

5 μm)

mobile phase of methanol-0.2% phosphoric acid(47:53)

detection wavelength 250 nm. Result: Optimal machine decoction process was as following:Soaked 10 minutes

decoction time 30 minutes

decoction temperature 105℃;it was better than traditional decoction process. Conclusion: Optimized machine decoction process was reasonable and feasible with controllable evaluation index

it could provide experimental basis for developing of machine decoction process of Chinese medicine decoctions.

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Related Institution

College of Pharmaceutical Science, Yunnan University of Traditional Chinese Medicine

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School of Graduate Studies，Tianjin University of Traditional Chinese Medicine

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