Effects of Emulsion on  Transdermal Absorption of Active Ingredients from inseng Radix et Rhizoma

MA Dong; LIU Meng; LI Chao-ying; GAO Ya-yan; YU Hui-chao; HE Rui

doi:10.11653/syfj2013230050

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Effects of Emulsion on Transdermal Absorption of Active Ingredients from inseng Radix et Rhizoma

更新时间：2024-01-04

- Effects of Emulsion on Transdermal Absorption of Active Ingredients from inseng Radix et Rhizoma
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 23, Pages: 50-53(2013)
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- DOI：10.11653/syfj2013230050
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- Published：2013
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MA Dong, LIU Meng, LI Chao-ying, et al. Effects of Emulsion on Transdermal Absorption of Active Ingredients from inseng Radix et Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 50-53.
DOI：

MA Dong, LIU Meng, LI Chao-ying, et al. Effects of Emulsion on Transdermal Absorption of Active Ingredients from inseng Radix et Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 50-53. DOI： 10.11653/syfj2013230050.

摘要

目的: 考察人参提取液和人参乳膏中有效成分的体外透皮吸收能力。方法: 采用智能透皮吸收仪，以人参总皂苷和总多糖为考察指标，采用UV测定指标成分含量，通过体外释药试验考察人参提取液制备成乳膏前后指标成分的透皮吸收能力变化。结果: 人参乳膏中总皂苷透皮吸收过程符合一级方程，而人参乳膏中总多糖、人参提取液中总皂苷和总多糖的透皮吸收过程均符合Higuchi方程，2种成分的累积释药率分别为82.30%，67.53%。结论: 人参乳膏具有良好的透皮能力，可增加有效成分的透皮吸收，为其他透皮给药剂型的研制提供科学依据。

Abstract

Objective: To investigate in vitro transdermal absorption ability of active ingredients from ginseng extract and ginseng creams. Method: Taking intelligent transdermal absorption instrument

with total saponins and total polysaccharides from ginseng Radix et Rhizoma as indexes

which were determined by UV;Before and after ginseng extract were prepared into ginseng creams

percutaneous absorption capacity changes of index components were investigated by in vitro release test. Result: Transdermal absorption process of total saponins from ginseng creams was in line with the first-order equation

but total polysaccharides from ginseng creams and total saponins and total polysaccharides from ginseng extract were in line with Higuchi release equation;After been prepared into ginseng creams

cumulative release rates of these two ingredients were 82.30% and 67.53%

respectively. Conclusion: ginseng creams had good transdermal ability

it could increase transdermal absorption of effective components and provide a scientific basis for research of other transdermal formulations.

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