GAO Jun, ZHANG Qian-de, ZHANG Xi, et al. Effect of Yishen Hugu Decoction on Disused Osteoporosis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 179-182.
DOI:
GAO Jun, ZHANG Qian-de, ZHANG Xi, et al. Effect of Yishen Hugu Decoction on Disused Osteoporosis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 179-182. DOI: 10.11653/syfj2013230179.
Effect of Yishen Hugu Decoction on Disused Osteoporosis in Rats
Objective: To study the effect of Yishen Hugu decoction on the changes of the blood and urine biochemical levels
the bone structure
bone biomechanical properties in the rat disused osteoporosis. Method: Seventy SD rats were randomly divided into 7 groups:normal group
sham operation group
model group
high dose
medium dose and low dose of Yishen Hugu decoction group (52
26
16.25 g·kg-1)and positive control group (Drynaria fortunei 0.25 g· kg-1) with 10 rats in each group.The rats in the model group
high
medium
low dose group of Yishen Hugu decoction and positive control group were performed sciatic neurotomy.Normal group was given regular food and water other groups were gavaged Yishen Hugu decoction respectively
and the rats in positive control group were gavaged Drynaria fortunei. The blood and urine biochemical levels were measured
the femora biomechanical test and the tibia were decalcified and then stained with HE and Masson stain. Result: The differences of alkaline phosphatase(ALP)
osteocalcin(BGP)
tartrate-resistant acid phosphatase(TRACP)
hydroxyproline (HYP)/creatinine(Cr)
bone mineral density(BMD) and the numbers of nodes and free ends in model group and sham operation group were significant statically (P<0.01). After administration of Yishen Hugu decoction
those indexes in high
medium
low dose group of Yishen Hugu decoction were obviously higher or lower than that in model group (P<0.01). Conclusion: The disused osteoporosis can be prevented effectively by the Yishen Hugu decoction.
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Related Author
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Related Institution
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