Objective: To study inhibitory activity the different separation parts of Ferula sinkiangensis resin on HCT116 human colon cancer cell and determine its effective active site. Method: The effects of the different separate parts of F. sinkiangensis resin (petroleum ether parts

ethyl acetate parts

methanol parts) on colon cancer cells HCT116 proliferation and apoptosis were observed

IC50 and total apoptosis rate were used toevaluate tumor suppression activity performance by SRB and flow cytometry with cell concentration 1×105/mL

and drug concentration of 250

125

62.5

31.25

15.6 mg· L-1 (flow cytometry drug concentration was 62.5 mg· L-1). Result: IC50 of petroleum ether unit was 68.7 mg· L-1

the total apoptosis rate was (43.4±1.1)%;IC50 of ethyl parts:43.7 mg· L-1

total apoptosis rate was (56.2±0.9)%;IC50methanol Department of 59.6 mg· L-1

total apoptosis rate was (46.7±3.1)%. Conclusion: Ferula resin ethanol extract ethyl acetate fraction can promote their apoptosis

initially identified as anti-tumor activity in F.sinkiangensis resin parts.