ZHANG Xiao-ping, HOU Lin, NIE Ke, et al. Effects of Xingnao Yizhi Capsule on Learning and Memorizing Consolidation of Dysmnesia Mice Induced by Scopolamine Hydrobromide[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 228-230.
DOI:
ZHANG Xiao-ping, HOU Lin, NIE Ke, et al. Effects of Xingnao Yizhi Capsule on Learning and Memorizing Consolidation of Dysmnesia Mice Induced by Scopolamine Hydrobromide[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 228-230. DOI: 10.11653/syfj2013230228.
Effects of Xingnao Yizhi Capsule on Learning and Memorizing Consolidation of Dysmnesia Mice Induced by Scopolamine Hydrobromide
Objective: To study the effect of Xingnao Yizhi capsule on learning and memorizing consolidation of dysmnesia mice induced by scopolamine hydrobromide. Method: Sixty mice were divide into normal control group
model group
Huperzine-A group(0.05 mg· kg-1 )
Xingnao Yizhi capsule of high dose group
middle dose group and low dose group(179.2
89.6
44.8 mg· kg-1).After the intragastric administration twice a day respectively for 15 days
the learning and memory consolidation of dysmnesia model was induced by scopolamine hydrobromide intraperitoneal injection(5 mg· kg-1). Learning and memory function of various group rats were assessed with step-through test and step-down test;The content of malondiadehyde(MDA)
activity of superoxide dismutase(SOD) in brain tissue were detected. Result: Compared with model group
Xingnao Yizhi capsule(179.2 mg· kg-1)prolonged the latency periods of memory and significantly reduced the error times within 5 mins in dysmnesia groups (P<0.05)
increased the activity of SOD and decreased the content of MDA in brain tissue (P<0.05). Conclusion: Xingnao Yizhi capsule has protective effects on learning and memorizing consolidation of dysmnesia mice induced by scopolamine hydrobromide.
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Zhen-yun HAN
Dan-feng TIAN
Dong-hui WANG
Xue YU
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Yan-shu PAN
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Related Institution
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Dongfang Hospital, Beijing University of Chinese Medicine