Effects of Extracts of on Animal gastrointestinal Activity and Serum Levels of Motilin

ZHANG Dong; WU Guo-dong; GAO Hong-bo; XU Ji-hui

doi:10.11653/syfj2013230243

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Effects of Extracts of on Animal gastrointestinal Activity and Serum Levels of Motilin

更新时间：2024-01-04

- Effects of Extracts of on Animal gastrointestinal Activity and Serum Levels of Motilin
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 23, Pages: 243-246(2013)
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- DOI：10.11653/syfj2013230243
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- Published：2013
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ZHANG Dong, WU Guo-dong, GAO Hong-bo, et al. Effects of Extracts of on Animal gastrointestinal Activity and Serum Levels of Motilin[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 243-246.
DOI：

ZHANG Dong, WU Guo-dong, GAO Hong-bo, et al. Effects of Extracts of on Animal gastrointestinal Activity and Serum Levels of Motilin[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 243-246. DOI： 10.11653/syfj2013230243.

摘要

目的: 研究诃子醇提物对动物胃肠运动和血清胃动素含量的影响。方法: 将实验动物随机分为空白对照组、吗丁啉（小鼠0.005 g·kg-1，大鼠0.003 g·kg-1）组，诃子提取物高、中、低剂量组（小鼠3.5，1.75，0.875 g·kg-1，大鼠2.4，1.2，0.6 g·kg-1），按10 mL·kg-1给药，采用小鼠在体胃肠运动实验、放免法检测大鼠血清胃动素含量和家兔离体肠平滑肌运动实验，观察诃子提取物对正常小鼠胃排空、小肠推进运动和大鼠血清胃动素含量以及家兔离体肠平滑肌收缩的影响。结果: 诃子提取物高、中剂量对正常小鼠胃排空和小肠推进运动有显著抑制作用，可以降低大鼠血清胃动素的含量，对家兔离体肠平滑肌收缩有显著抑制作用，对氯化乙酰胆碱引起的肠平滑肌兴奋有显著拮抗作用（P<0.05或P<0.01）。结论: 诃子醇提物对动物胃肠运动有抑制作用，其作用途径可能与M胆碱受体有关。

Abstract

Objective: To study the effects of extracts of Terminalia chebula on animal gastrointestinal activity and serum levels of motilin(MTL). Method: Effects of the extracts of T. chebula on the evacuation of stomach

the propulsive movement of intestine

serum levels of motilin

and the contraction of isolated rabbit intestinal smooth muscle were observed by mice gastrointestinal activity test and isolated rabbit intestinal smooth muscle movement experiment. Result: The extracts of T. chebula could distinctly inhibited the evacuation of stomach and the propulsive movement of intestine in mice

significantly reduce serum levels of motilin

also inhibit the contraction of isolated rabbit intestinal smooth muscle. The extracts of T. chebula showed significant antagonistic effect on spasmodic muscle of duodenum due to acetylcholine chloride. Conclusion: The extracts of T. chebula could inhibit animal gastrointestinal activity

the mechanism of which may be associated with M-receptor.

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Related Author

HE Jinbo

MAO Zhengrong

AI Shen

CHE Yan-zhong1

CHEN Hong-bao1

AN Li-feng2

CHANG Li1

FAN Xiao-yong1

Related Institution

First Affiliated Hospital of Henan University of Chinese Medicine

Department of Chinese Traditional Medicine,Guangzhou General Hospital, Guangzhou Military Command

General Hospital of Tianjin Medical University

1),CHEN Hong-bao~1,AN Li-feng~2,CHANG Li~1,FAN Xiao-yong~1

黑龙江中医药大学

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