Objective: The purpose is to study the clinical curative effect and mechanism action of Sanjie Zhentong capsule in treatment of pelvic inflammatory mass. Method: Ninety-five cases of patients were randomly divided into observation group (48 cases) and control group (47 cases) by digital method. The patients in control group were injected with levofloxacin injection(0.2×100)mL

gtt

2 times/day

metronidazole 200 mL· d-1

course of treatment 10 days. The patients not cured after 10 days could take another course of treatment. Based on the treatment of control group

the patients in observation group took Sanjie Zhentong capsule

1.6 g/time

3 times/day

course of treatment fourteen days. The main clinical symptom scores were recorded

using ultrasound to evaluate the size of package block. Hemodynamic indexes and levels of serum IL-6 and TNF-α were tested before and after treatment. Result: The total effective rate of observation group was 95.7%

superior to 78.7% in the control group (P<0.05). The levels of serum IL-6 and TNF-α of two groups all decreased after treatment

and the observation group was lower than control group (P<0.01). After treatment

the whole blood viscosity (low

medium

high)

red blood cells deposition

improvement of cell aggregation index

plasma viscosity of observation group were superior to control group (P<0.01). The lower abdomen pain

lumbosacral pain

aggravation in abdominal pain

increased uterine activity tenderness score

the line thicken and tenderness of attachment region

the size of the enclosed mass in attachment region

the thicken and tenderness of palace skeletons ligament

and total score of observation group were significantly decreased and were lower than the control group (P<0.01). Under ultrasound

the diameter of the enclosed mass was smaller than that of control group

and the difference of reducing of the observation group was better than that of control group (P<0.01). Conclusion: The clinical effect of Sanjie Zhentong capsules is good in the treatment of inflammatory block caused by chronic pelvic inflammation. Its mechanism may improve microcirculation and alleviate inflammatory reaction.