The pharmacological activities

mechanism and toxicity of research literature about Protocatechuic aldehyde was introduced to provide a reference for reasonable application and quality evaluation of new drug development contained in Salvia miltiorrhiza and protocatechuic aldehyde over the past thirty years. Protocatechuic aldehyde

one degradation compound of Salvianolic acid B found in the roots of S. miltiorrhiza

has an extensive pharmacological activities such as antiatherosclerosis

cardiomyocyte protection

antithrombus

neuroprotection and et al. Its mechanism have been investigated gradually. But Protocatechuic aldehyde is toxic to heart according to some tests. Prescription including S. miltiorrhiza of New drugs about cardiocerebral vascular disease is one of hotspot. therefore

it should be paid attention to process optimization of extraction and drug standard improving the efficacy in case of toxic and side effect.