REN Qiu-xia, WANG Ya-nan, QU Xin-yan, et al. Preparation and Evaluation of Self-Microemulsifying Drug Delivery System Containing Amentoflavone[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 5-9.
DOI:
REN Qiu-xia, WANG Ya-nan, QU Xin-yan, et al. Preparation and Evaluation of Self-Microemulsifying Drug Delivery System Containing Amentoflavone[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 5-9. DOI: 10.11653/syfj2013240005.
Preparation and Evaluation of Self-Microemulsifying Drug Delivery System Containing Amentoflavone
Objective: To develop a self-microemulsifying drug delivery system (SMEDDS) for amentoflavone (AMF) and evaluate its quality. Method: The amount and type of excipients was screened by solubility test
compatibility of oil and surfactant and pseudo-ternary phase diagram
formulation technology of AMF-SMEDDS was optimized by comparing appearance
particle size
self-microemulsifying time and drug loading of different prescriptions
then physicochemical characteristics
in vitro release and stability of AMF-SMEDDS were determined. Result: The best prescription of AMF-SMEDDS was as following:mAMF:mcremophor EL-35:methyl oleate:m1
2-propanediol(5.0:47.5:19.0:28.5);After being diluted with water
AMF-SMEDDS consisted of small spherical droplets with the mean particle size of (15.37±0.09) nm and Zeta potential of (-17.1±0.24) mV
microemulsion could quickly complete release of AMF at different pH medium. Conclusion: AMF-SMEDDS could significantly improve in vitro dissolution of AMF
and its preparation technology was stable and simple.
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Related Author
Xu-long CHEN
Xin-li LIANG
Huan LIU
Guo-wei ZHAO
Jia-hao WEN
Liao-qi OUYANG
Qie-ying JIANG
Zheng-gen LIAO
Related Institution
Key Laboratory of Modern Preparation of Traditional Chinese Medicine (TCM), Ministry of Education,Experimental Animal Science and Technology Center, Jiangxi University of TCM