Optimization of Vacuum-Belt Drying Process for Fangji Huangqi Granules

ZHANG Jian-ling; ZHANG Lu; LI Shi-dong; ZHANG Yan; WANG Lin-ge

doi:10.11653/syfj2013240010

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Optimization of Vacuum-Belt Drying Process for Fangji Huangqi Granules

更新时间：2024-01-04

- Optimization of Vacuum-Belt Drying Process for Fangji Huangqi Granules
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 24, Pages: 10-12(2013)
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- DOI：10.11653/syfj2013240010
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- Published：2013
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ZHANG Jian-ling, ZHANG Lu, LI Shi-dong, et al. Optimization of Vacuum-Belt Drying Process for Fangji Huangqi Granules[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 10-12.
DOI：

ZHANG Jian-ling, ZHANG Lu, LI Shi-dong, et al. Optimization of Vacuum-Belt Drying Process for Fangji Huangqi Granules[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 10-12. DOI： 10.11653/syfj2013240010.

摘要

目的：优选防己黄芪颗粒的真空带式干燥工艺条件。方法：采用HPLC测定粉防己碱、防己诺林碱及黄芪甲苷含量。以干燥物含水量、粉防己碱和防己诺林碱的总含量、黄芪甲苷含量的综合评分为指标，通过正交试验考察干燥温度、履带速度、进料速度对防己黄芪颗粒真空带式干燥工艺的影响。结果：最佳真空带式干燥工艺条件为3个干燥区的温度依次为80，85，80℃，履带速度20 cm·min-1，进料速度12 L·h-1；含水量4.58%，粉防己碱和防己诺林碱总提取量11.97 mg·g-1，黄芪甲苷提取量0.54 mg·g-1。结论：优选的干燥工艺具有干燥速率高、产品质量好等优点，符合GMP要求，为防己黄芪颗粒的工业化生产提供实验依据。

Abstract

Objective: To optimize vacuum-belt drying process of Fangji Huangqi granules. Method: HPLC was adopted to determine contents of tetrandrine

fangchinoline and astragaloside.With moisture content

total content of tetrandrine and fangchinoline

content of astragaloside as comprehensive evaluating indexes

orthogonal test was used to optimize vacuum-belt drying process of Fangji Huangqi granules with drying temperature

charging rate and belt speed as factors. Result: Optimal vacuum-belt drying process parameters were as follows:temperature of three heated regions at 80

80℃

belt speed of 20 cm·min-1

feeding rate of 12 L·h-1

moisture content 4.58%

total content of tetrandrine and fangchinoline 11.97 mg·g-1

content of astragaloside 0.54 mg·g-1. Conclusion: Optimized vacuum-belt drying technology had advantages of high drying rate

good product quality and so on.This study could provide a reasonable basis for industrial production of Fangji Huangqi granules in line with the GMP requirements.

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