Preparation and Prescription Optimization of Talci Pulvis Dispersible Tablets

WANG Nian-ming; LI Nan; YANG Feng-mei; HUANG Jing; QIN Chun-feng; YANG Ming

doi:10.11653/syfj2013240013

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Preparation and Prescription Optimization of Talci Pulvis Dispersible Tablets

更新时间：2024-01-04

- Preparation and Prescription Optimization of Talci Pulvis Dispersible Tablets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 24, Pages: 13-16(2013)
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- DOI：10.11653/syfj2013240013
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- Published：2013
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WANG Nian-ming, LI Nan, YANG Feng-mei, et al. Preparation and Prescription Optimization of Talci Pulvis Dispersible Tablets[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 13-16.
DOI：

WANG Nian-ming, LI Nan, YANG Feng-mei, et al. Preparation and Prescription Optimization of Talci Pulvis Dispersible Tablets[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 13-16. DOI： 10.11653/syfj2013240013.

摘要

目的：制备滑石粉分散片并优选其处方工艺。方法：以崩解时限、分散均匀性或软材成型情况为指标，通过单因素试验筛选滑石粉分散片的辅料种类；选取滑石粉、崩解剂、填充剂用量为考察因素，以崩解时限、分散均匀性和混悬稳定性为综合评价指标，采用综合评分法和D-最优混料设计优选滑石粉分散片处方。结果：最佳制备工艺为以微晶纤维素为填充剂，含羟丙基甲基纤维素（HPMC）的30%乙醇溶液为黏合剂，交联聚乙烯吡咯烷酮（PVPP）为崩解剂，最优处方比例为滑石粉-微晶纤维素-PVPP（0.447:0.400:0.123）。结论：优选的制备工艺稳定可行；D-最优混料设计可用于滑石粉分散片处方的优化，建立的数学模型具有良好预测性。

Abstract

Objective: To prepare Talci Pulvis dispersible tablets and optimized its prescription process. Method: Wtih disintegration time

dispersible uniformity or soft material molding conditions as indexes

excipients species of Talci Pulvis dispersible tablets were screened by single factor tests;With the amount of Talci Pulvis

disintegrating agents and stuffing bulking agents as factors

comprehensive scoring method and D-optimal mixture design were adopted to optimize prescription of Talci Pulvis dispersible tablets by taking disintegration time

dispersible uniformity and suspension stability as indicators. Result: Optimal preparation technology was as following:with microcrystalline cellulose(MCC) as a filler

30% ethanol configured hydroxy propyl methyl cellulose(HPMC) as a binder

cross-linked polyvinylpyrrolidone(PVPP) as a disintegrating agent;The best proportion of prescriptions was Talci Pulvis-MCC-PVPP (0.447:0.400:0.123). Conclusion: Optimized preparation tehcnology was stable and feasible; Established mathematical model of D-optimal mixture design had good predictability which could be used to optimize prescription of Talci Pulvis dispersible tablets.

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