Objective: To optimize forming technology of Xihuang dropping pills. Method: With dissolved time

appearance quality and weight variation of dropping pills as comprehensive evaluation index

based on single factor tests

orthogonal test was used to optimize molding technology by taking ratio of drug-matrix

dropping temperature

refrigerant temperature and dropping distance as factors. Result: Optimum forming technology conditions of Xihuang dropping pills were as follows:with PEG8000-PEG10000 (1:1) as matrix

ratio of drug and matrix 1:1.5

dimethyl silicone oil 100 as refrigerant

liquid temperature at 75℃

refrigerant temperature with a gradient cooling model(30℃ as upper temperature and 0-5℃ as the lower temperature)

dropping velocity of 20-25 drops per minute

dropping distance 4 cm. Conclusion: This optimized technology of Xihuang dropping pills was feasible and stable

it could provide a reference for clinical practice of Xihuang dropping pills.