Quality Standards Research of Kexinkang Tablets

DANG Xiao-wei; LI Jun; MAO Hong-yu; SHANG Chun-li

doi:10.11653/syfj2013240111

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Quality Standards Research of Kexinkang Tablets

更新时间：2024-01-04

- Quality Standards Research of Kexinkang Tablets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 24, Pages: 111-113(2013)
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- DOI：10.11653/syfj2013240111
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- Published：2013
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DANG Xiao-wei, LI Jun, MAO Hong-yu, et al. Quality Standards Research of Kexinkang Tablets[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 111-113.
DOI：

DANG Xiao-wei, LI Jun, MAO Hong-yu, et al. Quality Standards Research of Kexinkang Tablets[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 111-113. DOI： 10.11653/syfj2013240111.

摘要

目的：建立咳欣康片质量控制方法。方法：采用薄层色谱法（TLC）对咳欣康片处方中桔梗、黄芩、甘草进行定性鉴别；采用HPLC测定制剂中苦杏仁苷的含量。资生堂CAPCELL PAK C18MG色谱柱（4.6 mm×250 mm，5 μm），乙腈-甲醇-水-醋酸（7:7:86:0.02）为流动相，检测波长215 nm，流速1 mL·min-1。结果：桔梗、黄芩、甘草的TLC鉴别法专属性强，简单可行。HPLC含量测定，苦杏仁苷在0.044~0.327 g·L-1与峰面积呈良好的线性关系（r=0.999 5，n=7），苦杏仁苷的平均回收率为98.9%，RSD 1.2%。结论：该试验建立的方法简便快捷，重复性好，能更为有效的控制咳欣康片的质量。

Abstract

Objective: To establish a quality control method of Kexinkang tablets. Method: Platycodonis radix

Scutellariae radix

Glycyrrhizae radix rhizoma were identified by TLC

respectively. Amygdalin in Kexinkang tablets was determined by HPLC.The chromatographic column was the Shiseido CAPCELL PAK C18 MG(4.6 mm×250 mm

5 μm).The mobile phase consisted acetonitrile-methanol-water-acetic acid(7:7:86:0.02).The detection wavelength was 210 nm;the flow rate was 1.0 mL·min-1. Result: TLC was a specific method for the identification of Kexinkang tablets. Ursolic acid showed a good linear relation in the range of 0.044-0.327 g·L-1 (r=0.999 5

n=7)

the average recovery was 98.9% with RSD of 1.2%. Conclusion: The method is simple

sensitive and reproducible. It can be used to control the quality of Kexinkang tablets.

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