LIU Jin, SUI Zai-yun, WANG Ai-jie, et al. Effects of Shuxiong Capsule Micropowder on Whole Blood Viscosity and Platelet Activity of Rats with Acute Blood Stasis[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 181-184.
DOI:
LIU Jin, SUI Zai-yun, WANG Ai-jie, et al. Effects of Shuxiong Capsule Micropowder on Whole Blood Viscosity and Platelet Activity of Rats with Acute Blood Stasis[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 181-184. DOI: 10.11653/syfj2013240181.
Effects of Shuxiong Capsule Micropowder on Whole Blood Viscosity and Platelet Activity of Rats with Acute Blood Stasis
Objective: To study the effect of Shuxiong capsule micropowder on whole blood viscosity and the alpha-granular membrane protein(GMP-140) as well as thrombomodulin(TM) content of blood plasma of rats with acute blood stasis. Methold:Sixty rats were randomly divided into six groups as following:the group of Shuxiong capsule micropowder 0.094 5 g·kg-1
the group of Shuxiong capsule micropowder 0.283 5 g·kg-1
the group of shuxiong capsule 0.094 5 g·kg-1
the group of shuxiong capsule 0.283 5 g·kg-1 as well as blank and model groups. After administration for 14 days continuously
acute blood stasis models were replicated by means of epinephrine in ice-bath. Then the effects of shuxiong capsule micropowder on whole blood viscosity and the GMP-140 as well as TM content of blood plasma of model rats were observed. Result: When compared with blank group
the model rats' whole blood low
moderate and high cuts viscosity as well as the GMP-140 and TM content of blood plasma all rise remarkably.Compared with model group
the Shuxiong capsule micropowder and Shuxiong capsule can decreased whole blood viscosity
GMP-140 and TM content of blood plasma. The group of Shuxiong capsule micropowder 0.283 5 g·kg-1 had better effect. Conclusion: The results stated that Shuxiong capsule micropowder can improve blood rheology behavior of rats with acute blood stasis and has remarkable function of activating blood circulation and eliminating stasis. The mechanism might be related to the reduction of the GMP-140 and TM content of blood plasma.
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Related Author
Qi-nan WU
Min XUE
Qian WANG
An-na XU
Da-wei WU
Jing-jing QIAO
WEI Bin1
LU Jin-sheng2
Related Institution
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, College of Pharmacy, Nanjing University of Chinese Medicine
Nanjing Children’s Hospital Affiliated to Nanjing Medical University
Chinese Medicine Institute of PLA General Hospital
Department of Pharmacology, Third Military Medical University
Department of Pharmacy, Daping Hospital, Third Military Medical University