Objective: To investigate the neuroprotective effects of forsythiaside on glutamate

low-glucose and low-serum

amyloid beta25~35 (Aβ25~35))-induced neurotoxicity in PC12 cell. Method: The glutamate (20 mmol·L-1)

low-glucose and low serum and Aβ25-35 induced (10 μmol·L-1) neurotoxicity models in PC12 cell were established and the neuroprotective effects of forsythiaside (0.1

1

5 μmol·L-1)on above models were observed. Result: Forsythiaside could improve the proliferation on PC12 cell and significantly reduced cell death induced by glutamate

low-glucose and low-serum and Aβ25-35.In addition

forsythiaside (0.1

1 μmol·L-1) significantly inhibited cell apoptosis induced by Aβ25-35. Conclusion: forsythiaside has neuroprotective effects on glutamate

low-glucose and low-serum and Aβ25-35-induced neurotoxicity in PC12 cell.