Objective: To observe the therapeutic effect of Guanxinshu capsule on myocardial ischemia induced by ligating coronary artery in rats. Method: Myocardial ischemia model was developed by ligating the anterior descendingbranch of left coronary artery in rats. The rats were randomly divided into normal control group

sham group

model group

Fufang Danshen pill 90 mg·kg-1 group(positive control)

Guanxinshu low and high dose group(raw materials 5.2

15.6 g·kg-1)

the rats were administered with medicine for 28 days. After the last administration

rat II lead electrocardiogram was recorded

the myocardial infarction was measured by triphenyltetrazolium chloride (TTC) staining method

prothrombin time(PT) and activated partial thromboplastin time(APTT) of plasma were detected

the activities of creatine kinase (CK)

isoenzyme of creatine kinase-MB(CK-MB)

lactate dehydrogenase(LDH) of serum and glutathione peroxidase(GSH-Px) in myocardial tissue were determined

the ventriculus sinister were dissected to assess the morphology by pathological grading. Result: Guanxinshu capsule could reduce the scope of myocardial infarct significantly(compared with sham group

there were significant difference

P<0.05)

inhibit the lowering of ST segment (P<0.05)

decrease the level of CK

CK-MB and LDH (P<0.05)

prolong the time of APTT (P<0.01)

increase the activity of GSH-Px (P<0.01)

and improve the pathological changes of myocardial cells. Conclusion: Guanxinshu capsule showed obvious therapeutic effects on myocardial ischemia induced by ligating the coronary artery in rats.