Effects of Jiedu Fuyang Fang on Inflammatory Factors in Type 2 Diabetic Rats

HUANG Jiang-rong; LI Yong-fa; DU Ya-ming; HUANG Wei; LI Xang-hua

doi:10.11653/syfj2013240214

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Effects of Jiedu Fuyang Fang on Inflammatory Factors in Type 2 Diabetic Rats

更新时间：2024-01-04

- Effects of Jiedu Fuyang Fang on Inflammatory Factors in Type 2 Diabetic Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 24, Pages: 214-217(2013)
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- DOI：10.11653/syfj2013240214
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- Published：2013
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HUANG Jiang-rong, LI Yong-fa, DU Ya-ming, et al. Effects of Jiedu Fuyang Fang on Inflammatory Factors in Type 2 Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 214-217.
DOI：

HUANG Jiang-rong, LI Yong-fa, DU Ya-ming, et al. Effects of Jiedu Fuyang Fang on Inflammatory Factors in Type 2 Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 214-217. DOI： 10.11653/syfj2013240214.

摘要

目的：探讨解毒扶阳方对2型糖尿病（T2DM）模型大鼠炎症因子的调节作用。方法：取雄性大鼠，随机分为正常对照组，高脂高糖模型（模型）组，模型+二甲双胍（降糖）组，模型+解毒扶阳（试药）高、中、低剂量组，共6组，除正常对照组外，其他各组按60 mg·kg-1剂量尾静脉一次性快速注射链脲佐菌素制备动物模型，并于模型制作当日各给药组大鼠分别ig给予药物治疗，每日1次，连续12周。每10 d称量各组动物体重1次；给药最后1 d取血测定空腹血糖；取血清采用酶联免疫吸附分析方法测定血清瘦素（LEP）、胰岛素（INS）、白细胞介素（IL）-1、IL-6、C-反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）水平，计算胰岛素敏感指数（ISI）。结果：实验结果显示，解毒扶阳方与模型组比较，低剂量组有显著差异。血清LEP与模型组比较，试药3个剂量组均显示有非常显著的差异。ISI与模型对照组比较，3个剂量组均有非常显著性的差异。与模型组比较，中剂量组IL-1具有显著差异，高剂量组具有非常显著性差异。解毒扶阳方对TNF-α含量有降低作用，与模型组比较，高、中、低3个剂量组均有非常显著差异。结果表明，对CRP也有调节作用，与模型组比较，高、中、低3个剂量组均具有非常显著的差异。结论：解毒扶阳方对T2DM所致血糖、LEP、INS、IL-1、IL-6、CRP、TNF-α含量升高，均有一定调节作用，使之降到正常或接近正常水平。提示解毒扶阳方对T2DM所致炎症因子含量升高以及糖代谢紊乱，有调节作用。

Abstract

Objective: To study the effect of Jiedu Fuyang Fang on inflammatory factorstype 2 in diabetes mellitus (T2DM) rats. Method: The rat T2DM model was established by feeding of high fat and sugar diet and the intravenous injection of 60 mg·kg-1 streptozotocin(STZ). The corresponding drugs were given for 12 weeks. The serum was collected for the determination of leptin (LEP) pigment

and insulin (INS)

and white cell between pigment interleukin(IL)-1

and IL-6

and C-reactive protein (CRP)

and tumor necrosis factor-α (TNF-α) level

insulin sensitive index(ISI) was calculated. Result: Jiedu Fuyang Fang decreased inflammatory cytokines like IL-1

IL-6

CRP

TNF-α level

blood sugar

insulin and leptin content

and ISI. Conclusion: Jiedu Fuyang Fang has a impact on inflammatory factors in T2DM rise and regulate disorders of glucose metabolism.

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Related Institution

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